NQO1 Protein (His tag)

Produktnummer ABIN7197091

Produktdetails

Target: NQO1 (NAD(P)H Dehydrogenase, Quinone 1 (NQO1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses NQO1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human NQO1/DT-diaphorase Protein (His Tag)

Sequenz: Met 1-Lys274

Produktmerkmale: A DNA sequence encoding the mature form of human NQO1 (P15559-1) (Met1-Lys274) was expressed with a polyhistide tag at the N-terminus.

Reinheit: > 90 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: NQO1 (NAD(P)H Dehydrogenase, Quinone 1 (NQO1))

Andere Bezeichnung: NQO1/DT-diaphorase (NQO1 Produkte)

Synonyme: zgc:77191 Protein, wu:fb63c10 Protein, nqo1 Protein, DHQU Protein, DIA4 Protein, DTD Protein, NMOR1 Protein, NMORI Protein, QR1 Protein, Dia4 Protein, AV001255 Protein, Dtd Protein, Nmo-1 Protein, Nmo1 Protein, Nmor1 Protein, Ox-1 Protein, Ox1 Protein, Qr1 Protein, NADPH-d Protein, NAD(P)H dehydrogenase, quinone 1 Protein, NAD(P)H quinone dehydrogenase 1 Protein, NAD(P)H dehydrogenase, quinone 1 L homeolog Protein, nqo1 Protein, NQO1 Protein, Bpet2092 Protein, nqo1.L Protein, Nqo1 Protein

Hintergrund:

Background: NQO1 gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. NQO1 forms homodimers and reduces quinones to hydroquinones. NQO1's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in NQO1 gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of NQO1 has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Recent pharmacological research suggests feasibility of genotype-directed redox chemotherapeutic intervention targeting NQO1 breast cancer, a common missense genotype encoding a functionally impaired NQO1 protein.

Synonym: DHQU,DIA4,DTD,NMOR1,NMORI,QR1

Molekulargewicht: 33 kDa