MVK Protein (GST tag,His tag)

Produktnummer ABIN7197016

Produktdetails

Target: MVK (Mevalonate Kinase (MVK))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Aufreinigungstag / Konjugat: Dieses MVK Protein ist gelabelt mit GST tag,His tag.

Verwendungszweck: Recombinant Human MVK/Mevalonate kinase Protein (His & GST Tag)

Sequenz: Met 1-Leu 396

Produktmerkmale: A DNA sequence encoding the human MVK (Q03426) (Met1-Leu396) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Reinheit: > 90 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Frozen, Liquid

Buffer: Supplied as sterile 20 mM Tris, 500 mM NaCl, 2 mM DTT, pH 7.4, 10 % glycerol

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Antigendetails

Target: MVK (Mevalonate Kinase (MVK))

Andere Bezeichnung: MVK/Mevalonate kinase (MVK Produkte)

Synonyme: F21A20.160 Protein, F21A20_160 Protein, MEVALONATE KINASE Protein, MVK Protein, mevalonate kinase Protein, DDBDRAFT_0168621 Protein, DDBDRAFT_0302479 Protein, DDB_0168621 Protein, DDB_0302479 Protein, LRBP Protein, MK Protein, MVLK Protein, POROK3 Protein, 2310010A05Rik Protein, AI256848 Protein, AI414037 Protein, zgc:103473 Protein, mevalonate kinase Protein, mvk Protein, hypothetical protein Protein, MVK Protein, MK Protein, MA_RS03165 Protein, PAB_RS02890 Protein, LMOf2365_0011 Protein, mvk Protein, RCI_RS14145 Protein, TGAM_RS08735 Protein, MMAH_RS07705 Protein, TAGG_RS01605 Protein, SHELL_RS02965 Protein, MVOL_RS03085 Protein, Igag_1464 Protein, VDIS_RS11260 Protein, MFER_RS04560 Protein, DESMU_RS01555 Protein, ARCVE_RS02955 Protein, MZHIL_RS05110 Protein, Mvk Protein

Hintergrund:

Background: Mevalonate kinase belongs to the GHMP kinase family, Mevalonate kinase subfamily. It can be found in a wide variety of organisms from bacteria to mammals. Mevalonate kinase may be a regulatory site in cholesterol biosynthetic pathway. Defects in mevalonate kinase can cause mevalonic aciduria (MEVA). It is an accumulation of mevalonic acid which causes a variety of symptoms such as psychomotor retardation, dysmorphic features, cataracts, hepatosplenomegaly, lymphadenopathy, anemia, hypotonia, myopathy, and ataxia. Defects in mevalonate kinase can also cause hyperimmunoglobulinemia D and periodic fever syndrome (HIDS). HIDS is an autosomal recessive disease characterized by recurrent episodes of unexplained high fever associated with skin rash, diarrhea, adenopathy (swollen, tender lymph nodes), athralgias and/or arthritis.

Synonym: LRBP,MK,MVLK,POROK3

Molekulargewicht: 70.2 kDa

UniProt: Q03426