MMP7 Protein (Fc Tag)

Produktnummer ABIN7196950

Produktdetails

Target: MMP7 (Matrix Metallopeptidase 7 (Matrilysin, Uterine) (MMP7))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses MMP7 Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Recombinant Human MMP7 Protein (Fc Tag)

Sequenz: Tyr 95-Lys 267

Produktmerkmale: A DNA sequence encoding the active form of human MMP7 (NP_002414.1) (Tyr 95-Lys 267) was expressed with the fused Fc region of human IgG1 at the N-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 100 mM Glycine, 10 mM NaCl, 50 mM Tris, pH 7.5

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: MMP7 (Matrix Metallopeptidase 7 (Matrilysin, Uterine) (MMP7))

Andere Bezeichnung: MMP7 (MMP7 Produkte)

Synonyme: MAT Protein, MPMM Protein, MMP-7 Protein, MPSL1 Protein, PUMP-1 Protein, matrilysin Protein, LOC727698 Protein, MMP7 Protein, Matrilysin Protein, matrix metallopeptidase 7 Protein, MMP7 Protein, Mmp7 Protein

Hintergrund:

Background: Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological and pathological processes such as morphogenesis, differentiation, angiogenesis, tissue remodeling, and tumor invasion. MMPs are synthesized as pro-enzymes and converted to active form by extracellular proteinases. MMP7, also referred to as matrilysin, is the smallest member of the MMP family and differs from other MMP members in that it lacks the C-terminal hemopexin-like domain. MMP7 is produced primarily by mucosal epithelia, and is capable of degrading various ECM proteins including proteoglycans, fibronectin, elastin and casein. This enzyme serves essential functions in both innate defense and wound healing, and appears to be one of the most important MMPs in human colon cancers. It has been reported that MMP7 contributes to tumor malignancy probably by cleaving cell surface proteins such as Fas ligand, degradation of IgG or inducing E-cadherin-mediated cell aggregation. In addition, matrilysin is also identified as a mediator of pulmonary fibrosis and a potential therapeutic target.

Synonym: MMP-7,MPSL1,PUMP-1

Molekulargewicht: 45.8 kDa

NCBI Accession: NP_002414

Pathways: Production of Molecular Mediator of Immune Response