KIRREL Protein (His tag)

Produktnummer ABIN7320809

Produktdetails

Target: KIRREL (NEPH1) (Kin of IRRE Like 1 (NEPH1))

Protein-Typ: Recombinant

Spezies: Maus

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses KIRREL Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse KIRREL1/NEPH1 Protein (His Tag)

Sequenz: Leu48-Leu525

Produktmerkmale: Recombinant Mouse KIRREL1 is produced by our Mammalian expression system and the target gene encoding Leu48-Leu525 is expressed with a 6His tag at the C-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: KIRREL (NEPH1) (Kin of IRRE Like 1 (NEPH1))

Andere Bezeichnung: KIRREL1/NEPH1 (NEPH1 Produkte)

Synonyme: NEPH1 Protein, 6720469N11Rik Protein, Kirrel1 Protein, Neph1 Protein, nephrin related Protein, kirre like nephrin family adhesion molecule 1 Protein, kin of IRRE like (Drosophila) Protein, Smp_104390 Protein, Smp_140170 Protein, KIRREL1 Protein, Kirrel Protein, Kirrel1 Protein

Hintergrund:

Background: Kin of irregular chiasm-like protein 1(Kirrel1), also known as Nephrin-like protein 1(Neph1), belongs to the immunoglobulin superfamily. Kirrel1 plays a significant role in the normal development and function of the glomerular permeability. It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1. The knockout of this gene could result in perinatal lethality accompanied by proteinuria, and effacement of glomerular podocytes. Kirrel1 is abundantly expressed in kidney and specifically expressed in podocytes of kidney glomeruli. Its' subunit interacts with TJP1/ZO-1 and with NPHS2/podocin (via the C-terminus) and interacts with NPHS1/nephrin (via the Ig-like domains). This interaction is dependent on KIRREL glycosylation. Kirrel1 also interacts when tyrosine-phosphorylated with GRB2.

Synonym: Kin of IRRE-like protein 1,Kin of irregular chiasm-like protein 1,Nephrin-like protein 1,Kirrel1,Neph1

Molekulargewicht: 53.4 kDa

UniProt: Q80W68

Pathways: Regulation of Actin Filament Polymerization