KPNB1 Protein (His tag)

Produktnummer ABIN7318615

Produktdetails

Target: KPNB1 (Karyopherin (Importin) beta 1 (KPNB1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses KPNB1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human KPNB1 Protein (His Tag)

Sequenz: Met 1-Ala876

Produktmerkmale: Recombinant Human Importin Subunit Beta-1 is produced by our E.coli expression system and the target gene encoding Met1-Ala876 is expressed with a 6His tag at the N-terminus.

Reinheit: > 85 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM Tris,1 mM DTT,30 % glycerol,0.1M Nacl, pH 8.0.

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Antigendetails

Target: KPNB1 (Karyopherin (Importin) beta 1 (KPNB1))

Andere Bezeichnung: KPNB1 (KPNB1 Produkte)

Synonyme: Afu1g15720 Protein, AO090005001133 Protein, imb1 Protein, impnb Protein, ipo1 Protein, ipob Protein, ntf97 Protein, IMB1 Protein, IPO1 Protein, IPOB Protein, Impnb Protein, NTF97 Protein, AA409963 Protein, importin beta-1 subunit Protein, Importin beta-1 subunit Protein, karyopherin (importin) beta 1 L homeolog Protein, importin beta 1 Protein, karyopherin subunit beta 1 Protein, karyopherin (importin) beta 1 Protein, AFUA_1G15720 Protein, AOR_1_1974174 Protein, Bm1_57540 Protein, PMAA_065830 Protein, AFLA_083750 Protein, TSTA_085870 Protein, BDBG_07509 Protein, MCYG_00039 Protein, kpnb1.L Protein, LOC100533387 Protein, KPNB1 Protein, Kpnb1 Protein

Hintergrund:

Background: Importin subunit beta-1(KPNB1) is a member of the importin beta family. KPNB1 contains 1 importin N-terminal domain and 19 HEAT repeats. It is involved in nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. Its functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. The import of proteins containing a classical nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits. Each of these subunits is part of the karyopherin family of proteins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. It mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5.

Synonym: Importin subunit beta-1, Importin-90, Karyopherin subunit beta-1, Nuclear factor p97, Pore targeting complex 97 kDa subunit, PTAC97, KPNB1, NTF97

Molekulargewicht: 98.6 kDa

UniProt: Q14974

Pathways: Protein targeting to Nucleus