JAM3 Protein (His tag)

Produktnummer ABIN7320269

Produktdetails

Target: JAM3 (Junctional Adhesion Molecule 3 (JAM3))

Protein-Typ: Recombinant

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses JAM3 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse JAM3/JAM-C Protein (His Tag)

Sequenz: Met 1-Asn 241

Produktmerkmale: A DNA sequence encoding the mouse JAM3 (NP_075766.1) extracellular domain (Met 1-Asn 241) was expressed, fused with a polyhistidine tag at the C-terminus.

Reinheit: > 94 % as determined by SDS-PAGE

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 50 mM Tris-Citrate, 300 mM NaCl, pH 6.5

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: JAM3 (Junctional Adhesion Molecule 3 (JAM3))

Andere Bezeichnung: JAM3/JAM-C (JAM3 Produkte)

Synonyme: JAM3 Protein, jam3 Protein, sr:nyz155 Protein, wu:fb30h11 Protein, wu:fc08c06 Protein, wu:fc13e04 Protein, wu:fc25g11 Protein, jamc.2 Protein, 1110002N23Rik Protein, JAM-3 Protein, JAM-C Protein, Jcam3 Protein, JAM-2 Protein, JAMC Protein, junctional adhesion molecule 3 Protein, junctional adhesion molecule 3b Protein, junctional adhesion molecule 3a Protein, junction adhesion molecule 3 Protein, JAM3 Protein, jam3b Protein, jam3a Protein, Jam3 Protein

Hintergrund:

Background: Junctional Adhesion Molecule C Protein & Antibody (JAM-C, JAM3 Protein) also known as Junctional adhesion molecule 3, JAM3, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily. It is an adhesion molecule expressed by endothelial cells (ECs) that plays a role in tight junction formation, leukocyte adhesion, and transendothelial migration. JAM-C is an adhesion molecule that is expressed on cells within the vascular compartment and epithelial cells and, to date, has been largely studied in the context of inflammatory events. JAM-C is also expressed in peripheral nerves and that this expression is localized to Schwann cells at junctions between adjoining myelin end loops. JAM-C is a component of the autotypic junctional attachments of Schwann cells and plays an important role in maintaining the integrity and function of myelinated peripheral nerves. JAM-C was recently shown to be a counter receptor for the leukocyte beta2-integrin Mac-1 (CD11b/CD18), thereby mediating interactions between vascular cells, particularly in inflammatory cell recruitment. JAM-C is up-regulated by oxidized low-density lipoprotein (LDL) and may thereby contribute to increased inflammatory cell recruitment during atherosclerosis. JAM-C may therefore provide a novel molecular target for antagonizing interactions between vascular cells in atherosclerosis. JAM-C was shown to undergo a heterophilic interaction with the leukocyte beta2 integrin Mac-1, thereby mediating interactions between vascular cells in inflammatory cell recruitment. JAM-C undergoes a homophilic interaction via the Arg64-Ile65-Glu66 motif on the membrane-distal Ig domain of the molecule. The homophilic interaction of JAM-C can mediate tumor cell-endothelial cell interactions and may thereby be involved in the process of tumor cell metastasis.

Synonym: 1110002N23Rik;JAM-3;JAM-C;Jcam3

Molekulargewicht: 25 kDa

NCBI Accession: NP_075766