JTB Protein (Fc Tag)

Produktnummer ABIN7317243

Produktdetails

Target: JTB (Jumping Translocation Breakpoint (JTB))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses JTB Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Recombinant Human Jumping Translocation Breakpoint/JTB Protein (Fc Tag)

Sequenz: Met 1-Leu105

Produktmerkmale: A DNA sequence encoding the human JTB (O76095-1) (Met1-Leu105) was fused with Fc region of mouse IgG at the C-terminus.

Reinheit: > 85 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: JTB (Jumping Translocation Breakpoint (JTB))

Andere Bezeichnung: Jumping Translocation Breakpoint/JTB (JTB Produkte)

Synonyme: HJTB Protein, HSPC222 Protein, PAR Protein, hJT Protein, Gm622 Protein, JTB Protein, jumping translocation breakpoint Protein, JTB Protein, Jtb Protein

Hintergrund:

Background: Jumping translocation breakpoint, also known as JTB, is a member of the JTB family. Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomalsegments jumping to various telomeres. JTB is expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts. It is required for normal cytokinesis during mitosis. JTB plays a role in the regulation of cell proliferation. It may be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly.

Synonym: hJT,HJTB,HSPC222,JTB,PAR

Molekulargewicht: 34.7 kDa