IL17RD Protein (His tag)

Produktnummer ABIN7317848

Produktdetails

Target: IL17RD (Interleukin 17 Receptor D (IL17RD))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses IL17RD Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human IL17RD Protein (His Tag)

Sequenz: Met 1-Arg 299

Produktmerkmale: A DNA sequence encoding the extracellular domain of human IL17RD (NP_060033.3) precursor (Met 1-Arg 299) was expressed with a C-terminal polyhistidine tag.

Reinheit: > 97 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: IL17RD (Interleukin 17 Receptor D (IL17RD))

Andere Bezeichnung: IL17RD (IL17RD Produkte)

Synonyme: IL17RD Protein, sef Protein, il-17rd Protein, il17rlm Protein, HH18 Protein, IL-17RD Protein, IL17RLM Protein, SEF Protein, 2810004A10Rik Protein, AI428510 Protein, Sef Protein, Sef-S Protein, RGD1565237 Protein, cb208 Protein, id:ibd2875 Protein, id:ibd5059 Protein, zgc:136328 Protein, interleukin 17 receptor D Protein, IL17RD Protein, il17rd Protein, Il17rd Protein

Hintergrund:

Background: Interleukin-17 receptor D (IL-17D) also known as Interleukin-17 receptor-like protein, is a member of interleukine-17 recepter family. IL-17RD functions as a feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. It may inhibit FGF-induced FGFR1 tyrosine phosphorylation, regulate the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK By similarity, and mediate JNK activation and may be involved in apoptosis. IL-17RD is found expressed in the neopallial cortex, rhombic lip and dorsal regions of the myelencephalon and in the frontal nasal process. IL-17RD is also expressed in the commissural plate and septal area of the forebrain and in the hippocampus, lens and optic cup. In the oral region, IL-17RD is expressed in the tongue and in the mesenchyme of the first branchial arch. It is also expressed in the developing inner ear. IL-17RD interacts with both IL-17R-Myc and IL-17RB-Myc. Both the intracellular and extracellular domains of IL-17RD interact with IL-17R. IL-17R forms a heteromeric complex with IL-17RD. Experiment results indicate that IL-17RD is able to affect IL-17R localization, suggesting that these two molecules are colocalized and associate with each other within cells. The fact that IL-17RD Delta ICD is unable to mediate IL-17 signaling but functions as a dominant-negative form indicates that the intracellular domain of IL-17RD is pivotal. In addition, IL-17RD interacts with the IL-17R downstream molecule TRAF6. It has been proposed that the IL-17RD intracellular domain interacts with IL-17R and TRAF6 to deliver the downstream signal.

Synonym: HH18,IL-17RD,IL17RLM,SEF

Molekulargewicht: 33.5 kDa

NCBI Accession: NP_060033

Pathways: Toll-Like Receptors Cascades