IL17RA Protein (His tag)
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- Target Alle IL17RA Proteine anzeigen
- IL17RA (Interleukin 17 Receptor A (IL17RA))
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
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Spezies
- Maus
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses IL17RA Protein ist gelabelt mit His tag.
- Verwendungszweck
- Recombinant Mouse IL17RA Protein (His Tag)(Active)
- Sequenz
- Met 1-Trp 322
- Produktmerkmale
- A DNA sequence encoding the mouse IL17RA (NP_032385.1) extracellular domain (Met 1-Trp 322) was fused with a polyhistidine tag at the C-terminus.
- Reinheit
- > 98 % as determined by SDS-PAGE
- Endotoxin-Niveau
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- 1. Measured by its binding ability in a functional ELISA. 2. Immobilized recombinant human IL17A at 2 μg/ml (100 μl/well) can bind biotinylated mouse IL17RA with a linear range of 1.28-6.4 ng/ml.
- Top Product
- Discover our top product IL17RA Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Lagerung
- 4 °C,-20 °C,-80 °C
- Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- IL17RA (Interleukin 17 Receptor A (IL17RA))
- Andere Bezeichnung
- IL17RA (IL17RA Produkte)
- Synonyme
- IL17R Protein, CANDF5 Protein, CD217 Protein, CDw217 Protein, IL-17RA Protein, hIL-17R Protein, Il17r Protein, AW538159 Protein, Cdw217 Protein, VDw217 Protein, interleukin 17 receptor A Protein, IL17RA Protein, Il17ra Protein
- Hintergrund
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Background: Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor which binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
Synonym: AW538159,Cdw217,Il17r,VDw217
- Molekulargewicht
- 34.8 kDa
- NCBI Accession
- NP_032385
- Pathways
- SARS-CoV-2 Protein Interaktom
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