IFNGR1 Protein (His tag)

Produktnummer ABIN7196273

Produktdetails

Target: IFNGR1 (Interferon gamma Receptor 1 (IFNGR1))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses IFNGR1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse IFNGR1/CD119 Protein (His Tag)(Active)

Sequenz: Met 1-Asp 253

Produktmerkmale: A DNA sequence encoding the mouse IFNGR1 (P15261) extracellular domain (Met 1-Asp 253) was expressed, with a polyhistidine tag at the C-terminus.

Reinheit: > 98 % as determined by SDS-PAGE

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by its ability to bind with recombinant mouse IFNG-Fc in a functional ELISA.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: IFNGR1 (Interferon gamma Receptor 1 (IFNGR1))

Andere Bezeichnung: IFNGR1/CD119 (IFNGR1 Produkte)

Synonyme: CD119 Protein, IFNGR Protein, IFN-gammaR Protein, Ifgr Protein, Ifngr Protein, Nktar Protein, IFNGR1 Protein, MGC129098 Protein, ifngr1 Protein, MGC194858 Protein, MGC194873 Protein, zgc:194858 Protein, cd119 Protein, ifngr Protein, DKFZp469K1232 Protein, interferon gamma receptor 1 Protein, cytokine receptor family member B17 Protein, IFNGR1 Protein, Ifngr1 Protein, crfb17 Protein, ifngr1 Protein

Hintergrund:

Background: The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD119 (cluster of differentiation 119), also known as IFNGR1 ( interferon gamma receptor 1), is part of the heterodimeric gamma interferon receptor which consists of IFNGR1 (CD119) and IFNGR2. The IFNGR1 gene encodes the ligand-binding chain (alpha) of the interteron receptor while IFNGR gene encodes the non-ligand binding partner. The ability of the interferon-γ was achieved through binding to the interferon receptor CD119. After binding, the products of activated T-lymphocytes interferon-γ exerts antiviral activity, growth inhibitory effect, and several immune- regulatory activities on a variety of cell types.

Synonym: CD119;Ifgr;IFN-gammaR;Ifngr;Nktar

Molekulargewicht: 27.4 kDa

UniProt: P15261

Pathways: Interferon-gamma Pathway