Hexosaminidase A Protein (HEXA) (His tag)

Produktnummer ABIN7317429

Produktdetails

Target: Hexosaminidase A (HEXA)

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Aufreinigungstag / Konjugat: Dieses Hexosaminidase A Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human HEXA Protein (Subunit A, His Tag)(Active)

Sequenz: Met 1-Thr 529

Produktmerkmale: A DNA sequence encoding the human HEXA (AAD13932.1) (Met 1-Thr 529) was fused with a polyhistidine tag at the C-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by its ability to hydrolyze 4-methylumbelliferyl-N-acetyl-β-D-glucosaminide (4-MU-Glc-NAc).The specific activity is >1,250 pmoles/min/μg.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: Hexosaminidase A (HEXA)

Andere Bezeichnung: HEXA (HEXA Produkte)

Synonyme: TSD Protein, fc04h11 Protein, wu:fc04h11 Protein, wu:fv09f06 Protein, si:dkey-35i22.2 Protein, HEXA Protein, Hex-1 Protein, zgc:112084 Protein, hexosaminidase subunit alpha Protein, hexosaminidase B (beta polypeptide) Protein, CUGBP Elav-like family member 6 Protein, hexosaminidase A Protein, hexosaminidase A (alpha polypeptide) Protein, beta-hexosaminidase subunit alpha-like Protein, HEXA Protein, hexb Protein, CELF6 Protein, Hexa Protein, hexa Protein, LOC100228061 Protein

Hintergrund:

Background: Wilms' tumor 1-associating protein (WTAP) was previously identified as a protein associated with Wilms' tumor-1 (WT-1) protein that is essential for the development of the genitourinary system. WT1 was originally identified as a tumor suppressor for Wilms' tumor, but it is also overexpressed in a variety of cancer cells. The WTAP-WT1 axis in vascular cells suggest that WTAP is a vital and multifaceted regulator of vascular remodeling. WTAP has been suggested to function in alternative splicing, stabilization of mRNA, and cell growth. Knocking down endogenous WTAP increased Smooth muscle cells (SMCs) proliferation, because of increased DNA synthesis and G(1)/S phase transition, together with reduced apoptosis. These effects could be the result of WTAP suppressing the transcriptional activity of WT1 in SMCs. WTAP may thus also play a role in messenger RNA processing in mammalian cells, either dependent on or independent of its interaction with WT1.

Synonym: TSD

Molekulargewicht: 59.7 kDa

Pathways: Sensory Perception of Sound, Glycosaminoglycan Metabolic Process