HFE2 Protein (His tag)

Produktnummer ABIN7317877

Produktdetails

Target: HFE2 (Hemochromatosis Type 2 (Juvenile) (HFE2))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Aufreinigungstag / Konjugat: Dieses HFE2 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Hemojuvelin/HFE2 Protein (His Tag)

Sequenz: Met 1-Ser 399

Produktmerkmale: A DNA sequence encoding the mature form of human HFE2 isoform a (Q6ZVN8-1) (Met 1-Ser 399) was fused with a polyhistidine tag at the C-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, 500 mM NaCl, pH 7.0, 10 % gly

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: HFE2 (Hemochromatosis Type 2 (Juvenile) (HFE2))

Andere Bezeichnung: Hemojuvelin/HFE2 (HFE2 Produkte)

Synonyme: HFE2A Protein, HJV Protein, JH Protein, RGMC Protein, HFE2 Protein, DKFZp468F2322 Protein, 2310035L15Rik Protein, 5230400G09Rik Protein, AI414844 Protein, AI789733 Protein, DL-M Protein, Rgmc Protein, hemojuvelin Protein, RGMr Protein, hjv Protein, id:ibd3464 Protein, wu:fb38f10 Protein, zgc:136698 Protein, hemochromatosis type 2 (juvenile) Protein, hemochromatosis type 2 Protein, HFE2 Protein, Hfe2 Protein, hfe2 Protein

Hintergrund:

Background: Hemojuvelin, also known as HFE2, is a membrane-bound and soluble protein which belongs to the repulsive guidance molecule (RGM) family. It is known that RGMs function through Neogenin, a homologue of the Netrin receptor deleted in colon cancer. In mammals, RGM family consists of three glycoproteins which have discrete expression patterns and functions (RGM-A, RGM-B, and RGM-C). Hemojuvelin is expressed in adult and fetal liver, heart, and skeletal muscle. Hemojuvelin acts as a bone morphogenetic protein (BMP) coreceptor. Enhancement of BMP signaling regulates hepcidin (HAMP) expression and iron metabolism. It plays a key role in iron metabolism. Hemojuvelin represents the cellular receptor for hepcidin. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. Defects in hemojuvelin are the cause of hemochromatosis type 2A, also known as juvenile hemochromatosis (JH).

Synonym: HFE2A,HJV,JH,RGMC

Molekulargewicht: 40 kDa

Pathways: Transition Metal Ion Homeostasis