HRSP12 Protein (His tag)

Produktnummer ABIN7318565

Produktdetails

Target: HRSP12 (Heat-Responsive Protein 12 (HRSP12))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses HRSP12 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human RIDA/HRSP12 Protein (His Tag)

Sequenz: Met 1-Leu137

Produktmerkmale: Recombinant Human Heat-Responsive Protein 12 is produced by our E.coli expression system and the target gene encoding Met1-Leu137 is expressed with a 6His tag at the N-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl, 100 mM NaCl, 1 mM DTT, 10 % Glycerol, pH 8.0.

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Antigendetails

Target: HRSP12 (Heat-Responsive Protein 12 (HRSP12))

Andere Bezeichnung: RIDA/HRSP12 (HRSP12 Produkte)

Synonyme: P14.5 Protein, PSP Protein, UK114 Protein, HR12 Protein, HRP12 Protein, PSP1 Protein, Psp Protein, HRSP12 Protein, zgc:101025 Protein, zgc:92739 Protein, reactive intermediate imine deaminase A homolog Protein, ribonuclease UK114 Protein, heat-responsive protein 12 Protein, ribonuclease UK114 pseudogene Protein, RIDA Protein, Rida Protein, LOC698724 Protein, LOC711809 Protein, NGR_b07070 Protein, LOC100353046 Protein, hrsp12 Protein

Hintergrund:

Background: Heat-Responsive Protein 12 (HRSP12) is an endoribonuclease that belongs to the Rut family. HRSP12 is found mainly in the human adult kidney and liver and is responsible for inhibiting protein translation by cleaving mRNA. HRSP12 only cleaves phosphodiester bonds in single-stranded RNA and inhibits cell-free protein synthesis. The levels of both mRNA and protein are markedly reduced in heptatocellular tumors and in human hepatoma cell lines compared with normal liver tissues. Moreover the levels of HRSP12 are different depending on the grade of the tumor. This had led to the suggestion that HRSP12 may be an important biomarker for heptatic carcinoma.

Synonym: Ribonuclease UK114, 14.5 kDa Translational Inhibitor Protein, p14.5, Heat-Responsive Protein 12, UK114 Antigen Homolog, HRSP12, PSP

Molekulargewicht: 16.7 kDa

UniProt: P52758