HSP70 1A Protein (His tag)

Produktnummer ABIN7317034

Produktdetails

Target: HSP70 1A (HSPA1A) (Heat Shock 70kDa Protein 1A (HSPA1A))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Aufreinigungstag / Konjugat: Dieses HSP70 1A Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human HSP70/HSPA1A Protein (His Tag)(Active)

Sequenz: Ala 2-Asp 641

Produktmerkmale: A DNA sequence encoding the human HSPA1A (NP_005337.2) (Ala2-Asp641) was expressed, with a polyhistidine tag at the N-terminus.

Reinheit: > 85 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: 1. Measured by its ability to bind human PARP1 in a functional ELISA.2. Measured by its ability to bind mouse PARP1 in a functional ELISA.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: HSP70 1A (HSPA1A) (Heat Shock 70kDa Protein 1A (HSPA1A))

Andere Bezeichnung: HSP70/HSPA1A (HSPA1A Produkte)

Synonyme: hsp70-4 Protein, hspa1a Protein, Hsp70-3 Protein, Hsp70.3 Protein, Hsp72 Protein, hsp68 Protein, hsp70A1 Protein, HSP72 Protein, Hsp70-1 Protein, Hspa1 Protein, Hspa1b Protein, hsp70-1 Protein, hsp70-1a Protein, hsp70i Protein, hsp72 Protein, hspa1 Protein, hspa1b Protein, HSP70-1 Protein, HSP70-1A Protein, HSP70I Protein, HSPA1 Protein, HSPA1A Protein, HSPA1B Protein, HSP70-2 Protein, HSPA2 Protein, HSP70 Protein, hspA1A Protein, heat shock cognate 70-kd protein, tandem duplicate 3 Protein, heat shock 70 kDa protein 1 Protein, heat shock 70 kDa protein II Protein, heat shock protein 1A Protein, heat shock 70kD protein 1A Protein, heat shock protein family A (Hsp70) member 1A S homeolog Protein, heat shock protein family A (Hsp70) member 1A Protein, heat shock protein 70.2 Protein, heat shock 70kDa protein 1A Protein, heat shock 70 kDa protein 1B Protein, heat shock protein 70.1 Protein, hsp70.3 Protein, LOC100023597 Protein, LOC100554002 Protein, LOC100608888 Protein, Hspa1a Protein, hspa1a.S Protein, HSPA1A Protein, HSP70.2 Protein, LOC100354037 Protein, HSP70.1 Protein

Hintergrund:

Background: HSPA1A is a member of the Hsp70 protein family. The 70 kilodalton heat shock proteins (Hsp70s) are a family of ubiquitously expressed heat shock proteins. HSP are abundant and conserved proteins present in all cells. Upon temperature shock or other stress stimuli, HSP are synthesized intracellularly, which may protect cells from protein denaturation or from death. Extracellularly, HSP can serve a cytokine function to initiate both innate and adaptive immunity through activation of APC. HSP serves also a chaperone function and facilitates presentation of antigen peptide to T cells. Molecular chaperones of the Hsp70 family have diverse functions in cells. They assist the folding of newly synthesized and stress-denatured proteins, as well as the import of proteins into organelles, and the dissociation of aggregated proteins. The well-conserved Hsp70 chaperones are ATP dependent: binding and hydrolysis of ATP regulates their interactions with unfolded polypeptide substrates, and ATPase cycling is necessary for their function. All cellular functions of Hsp70 chaperones use the same mechanism of ATP-driven polypeptide binding and release. 

Synonym: HEL-S-103;HSP70-1;HSP70-1A;HSP70I;HSP72;HSPA1

Molekulargewicht: 72.2 kDa

UniProt: P08107

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process