GAP43 Protein (His tag)

Produktnummer ABIN7195999

Produktdetails

Target: GAP43 (Growth Associated Protein 43 (GAP43))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses GAP43 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human GAP43/Neuromodulin Protein (His Tag)

Sequenz: Met 1-Ala 238

Produktmerkmale: A DNA sequence encoding the human GAP43 (P17677) (Met 1-Ala 238) was fused with a polyhistidine tag at the C-terminus.

Reinheit: > 96 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: GAP43 (Growth Associated Protein 43 (GAP43))

Andere Bezeichnung: GAP43/Neuromodulin (GAP43 Produkte)

Synonyme: B-50 Protein, PP46 Protein, Basp2 Protein, GAP-43 Protein, b-50 Protein, gap-43 Protein, gap43b Protein, pp46 Protein, cb310 Protein, gap Protein, gap43 Protein, gap43a Protein, growth associated protein 43 Protein, growth associated protein 43 L homeolog Protein, growth associated protein 43 S homeolog Protein, GAP43 Protein, Gap43 Protein, gap43.L Protein, gap43 Protein, gap43.S Protein

Hintergrund:

Background: Neuromodulin, also known as Axonal membrane protein GAP-43, Growth-associated protein 43, Neural phosphoprotein B-50, pp46 and GAP43, is a cell membrane protein which belongs to the neuromodulin family. Neuromodulin / GAP43 contains one IQ domain. Neuromodulin / GAP43 is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Neuromodulin / GAP43 is involved in neurite outgrowth, a crucial process for the differentiation of neurons. The sudden infant death syndrome (SIDS) is the main cause of postneonatal infant death and its cause is still unknown. Neuromodulin / GAP43 is a marker of synaptic plasticity and is critical for normal development of the serotonergic innervation. Neuromodulin / GAP43 is a major cortical cytoskeleton-associated and calmodulin binding protein that is widely and abundantly expressed during development, maintained in selected brain structures in the adult, and reinduced during nerve regeneration. CAP23 and GAP43 are functionally related intrinsic determinants of anatomical plasticity. These proteins function by locally promoting subplasmalemmal actin cytoskeleton accumulation.

Synonym: B-50;PP46

Molekulargewicht: 26.2 kDa

UniProt: P17677