GLIPR1 Protein (His tag)

Produktnummer ABIN7320125

Produktdetails

Target: GLIPR1 (GLI Pathogenesis-Related 1 (GLIPR1))

Protein-Typ: Recombinant

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses GLIPR1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse GLIPR1 Protein (His Tag)

Sequenz: Met1-Thr223

Produktmerkmale: A DNA sequence encoding the mouse GLIPR1 (NP_082884.1) (Met1-Thr223) was expressed with a C-terminal polyhistidine tag.

Reinheit: > 85 % as determined by SDS-PAGE

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: GLIPR1 (GLI Pathogenesis-Related 1 (GLIPR1))

Andere Bezeichnung: GLIPR1 (GLIPR1 Produkte)

Synonyme: CRISP7 Protein, GLIPR Protein, RTVP1 Protein, 2410114O14Rik Protein, RTVP-1 Protein, mRTVP-1 Protein, GLIPR1 Protein, zgc:65887 Protein, GLI pathogenesis related 1 Protein, GLI pathogenesis-related 1 Protein, GLI pathogenesis-related 1 (glioma) Protein, GLI pathogenesis-related 1b Protein, GLIPR1 Protein, Glipr1 Protein, glipr1b Protein

Hintergrund:

Background: Glioma pathogenesis-related protein 1, also known as Protein RTVP-1, GLIPR1 and GLIPR, is a single-pass membrane protein which belongs to the CRISP family. GLIPR1 / RTVP-1 was expressed in high levels in glioblastomas, whereas its expression in low-grade astrocytomas and normal brains was very low. Transfection of glioma cells with small interfering RNAs targeting GLIPR1 / RTVP-1 decreased cell proliferation in all the cell lines examined and induced cell apoptosis in some of them. Overexpression of GLIPR1 / RTVP-1 increased astrocyte and glioma cell proliferation and the anchorage-independent growth of the cells. In addition, overexpression of GLIPR1 / RTVP-1 rendered glioma cells more resistant to the apoptotic effect of tumor necrosis factor-related apoptosis-inducing ligand and serum deprivation. GLIPR1 / RTVP-1 regulated the invasion of glioma cells was evident by their enhanced migration through Matrigel and by their increased invasion in a spheroid confrontation assay. The increased invasive potential of the GLIPR1 / RTVP-1 overexpressors was also shown by the increased activity of matrix metalloproteinase 2 in these cells. The expression of GLIPR1 / RTVP-1 is correlated with the degree of malignancy of astrocytic tumors and that GLIPR1 / RTVP-1 is involved in the regulation of the growth, survival, and invasion of glioma cells. GLIPR1 / RTVP-1 is a potential therapeutic target in gliomas.

Synonym: 2410114O14Rik;mRTVP-1;RTVP-1;RTVP1

Molekulargewicht: 25.1 kDa

NCBI Accession: NP_082884

Pathways: Regulation of Lipid Metabolism by PPARalpha