GLA Protein (His tag)

Produktnummer ABIN7319202

Produktdetails

Target: GLA (Galactosidase, alpha (GLA))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses GLA Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Alpha-Galactosidase A/GLA Protein (His Tag)

Sequenz: Leu32-Leu429

Produktmerkmale: Recombinant Human alpha-Galactosidase is produced by our Mammalian expression system and the target gene encoding Leu32-Leu429 is expressed with a 6His tag at the C-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl, 150 mM NaCl, pH 8.0.

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Antigendetails

Target: GLA (Galactosidase, alpha (GLA))

Andere Bezeichnung: Alpha-Galactosidase A/GLA (GLA Produkte)

Synonyme: GALA Protein, Ags Protein, zgc:101584 Protein, MGC130872 Protein, SMU.877 Protein, SCF11.21 Protein, AO090005000217 Protein, alpha-GAL Protein, galactosidase alpha Protein, galactosidase, alpha Protein, galactosidase alpha S homeolog Protein, alpha-galactosidase Protein, aga Protein, alpha-galactosidase A Protein, GLA Protein, Gla Protein, gla Protein, gla.S Protein, agaN Protein, aga Protein, agaL Protein, SCO0541 Protein, rafA Protein, melA Protein, galA Protein, ANI_1_2528074 Protein, ANI_1_1502124 Protein, AOR_1_390174 Protein, CpipJ_CPIJ002066 Protein, MCYG_00962 Protein, MCYG_00791 Protein, Tsp_02909 Protein, Tsp_02508 Protein

Hintergrund:

Background: α-Galactosidase A is a homodimeric glycoprotein that belongs to the glycosyl hydrolase 27 family. It is a lysosomal enzyme and used as a long-term enzyme replacement therapy in patients with a confirmed diagnosis of Fabry disease. α-Galactosidase A can hydrolyze terminal α-galactosyl moieties from glycolipids and glycoproteins and catalyze the hydrolysis of melibiose into galactose and glucose. Defects α-Galactosidase A are the cause of Fabry disease (FD) which is a rare X-linked sphingolipidosis disease with glycolipid accumulates in many tissues. The disease consists of an inborn error of glycosphingolipid catabolism. FD patients show systemic accumulation of globotriaoslyceramide (Gb3) and related glycosphingolipids in the plasma and cellular lysosomes throughout the body. Patients may show ocular deposits, febrile episodes, and burning pain in the extremities. Death results from renal failure, cardiac or cerebral complications of hypertension or other vascular disease.

Synonym: Alpha-Galactosidase A, Alpha-D-Galactosidase A, Alpha-D-Galactoside Galactohydrolase, Melibiase, Agalsidase, GLA,GLAL

Molekulargewicht: 46.4 kDa

UniProt: P06280

Pathways: SARS-CoV-2 Protein Interaktom