Follistatin Protein (FST) (Fc Tag)

Produktnummer ABIN7320424

Produktdetails

Target: Follistatin (FST)

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Maus

Quelle: CHO Cells

Aufreinigungstag / Konjugat: Dieses Follistatin Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Recombinant Mouse Follistatin/FST (FS288) Protein (Fc Tag)(Active)

Sequenz: Met 1-Asn 317

Produktmerkmale: A DNA sequence encoding the mouse FST (P47931) (Met 1-Asn 317) was expressed with the Fc region of human IgG1 at the C-terminus.

Reinheit: > 90 % as determined by SDS-PAGE

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation.The ED50 for this effect is typically 40-200 ng/mL in the presence of 10 ng/mL rhActivin A.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: Follistatin (FST)

Andere Bezeichnung: Follistatin/FST (FST Produkte)

Synonyme: CG12955 Protein, CG12956 Protein, CG33466 Protein, Dmel\\CG33466 Protein, Fol1 Protein, dFS Protein, dFol1 Protein, dfs Protein, fs Protein, FS Protein, foll Protein, xfs Protein, FST Protein, fst Protein, AL033346 Protein, FOL1 Protein, Fst-288 Protein, RATFOL1 Protein, cb446 Protein, fd07h10 Protein, fst1 Protein, wu:fd07h10 Protein, Follistatin Protein, follistatin Protein, follistatin L homeolog Protein, follistatin a Protein, Fs Protein, fst Protein, FST Protein, LOC100141662 Protein, fst.L Protein, Fst Protein, fsta Protein

Hintergrund:

Background: Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. follistatin are expressed and subserve local regulatory roles in numerous extragonadal tissues, including brain, adrenal, bone marrow, and placenta but perhaps most notably in anterior pituitary-the classical target tissue for inhibin, the activin-follistatin system may play a key role in early embryogenesis. Follistatin binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone follistatin is a binding protein to activin. Since activin binds to follistatin, it is imperative to determine the nature of the activin/follistatin binding complex.

Synonym: AL033346,FS

Molekulargewicht: 58.4 kDa

UniProt: P47931

Pathways: Negative Regulation of Hormone Secretion