FAM3B Protein (Fc Tag)

Produktnummer ABIN7319765

Produktdetails

Target: FAM3B (Family with Sequence Similarity 3, Member B (FAM3B))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses FAM3B Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Recombinant Human FAM3B (C-Fc)

Sequenz: Glu30-Ser235

Produktmerkmale: Recombinant Human Protein FAM3B is produced by our Mammalian expression system and the target gene encoding Glu30-Ser235 is expressed with a Fc tag at the C-terminus.

Reinheit: >95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: FAM3B (Family with Sequence Similarity 3, Member B (FAM3B))

Andere Bezeichnung: FAM3B (FAM3B Produkte)

Synonyme: 2-21 Protein, C21orf11 Protein, C21orf76 Protein, ORF9 Protein, PANDER Protein, 9030624C24Rik Protein, D16Jhu19e Protein, Pander Protein, RGD1311662 Protein, family with sequence similarity 3 member B Protein, family with sequence similarity 3, member B Protein, FAM3B Protein, Fam3b Protein

Substanzklasse: Viral Protein

Hintergrund:

Background: FAM3B, also known as Pancreatic-derived factor (PANDER), is an islet-specific secreted cytokine specifically expressed at high levels in the islets of Langerhans of the endocrine pancreas. FAM3B can induce apoptosis of alpha and beta cells in a dose- and time-dependent manner. Previous studies showed that FAM3B regulates glucose and lipid metabolism through interaction with liver and endocrine pancreas. FAM3B silencing activates both extrinsic and intrinsic apoptotic pathways. In general, silencing FAM3B promoted p53 phosphorylation and induced p53 accumulation by decreasing Mdm2 expression, which resulted in apoptotic cell death.

Synonym: Sialic acid-binding Ig-like lectin 9,Siglec-9,CDw329,Protein FOAP-9,SIGLEC9

Molekulargewicht: 50 kDa

UniProt: P58499

Pathways: Hormone Transport