EDEM2 Protein (His tag)

Produktnummer ABIN7317170

Produktdetails

Target: EDEM2 (ER Degradation Enhancer, Mannosidase alpha-Like 2 (EDEM2))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses EDEM2 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human EDEM2/C20orf31 Protein (His Tag)

Sequenz: Met 1-Lys492

Produktmerkmale: A DNA sequence encoding the human EDEM2 (AAH01371.1) (Met1-Lys492) was expressed with a polyhistidine tag at the C-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: EDEM2 (ER Degradation Enhancer, Mannosidase alpha-Like 2 (EDEM2))

Andere Bezeichnung: EDEM2/C20orf31 (EDEM2 Produkte)

Synonyme: C20orf31 Protein, C20orf49 Protein, bA4204.1 Protein, 9530090G24Rik Protein, AI327354 Protein, RGD1303074 Protein, MGC88910 Protein, DKFZp459A0314 Protein, ER degradation enhancing alpha-mannosidase like protein 2 Protein, ER degradation enhancer, mannosidase alpha-like 2 Protein, EDEM2 Protein, Edem2 Protein, edem2 Protein

Hintergrund:

Background: EDEM2, also known as C20orf31, belongs to a family of proteins involved in ER-associated degradation (ERAD) of glycoproteins. In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome. Early in this pathway, a proposed lumenal ER lectin, EDEM, recognizes misfolded glycoproteins in the ER, disengages the nascent molecules from the folding pathway, and facilitates their targeting for disposal. In humans there are a total of three EDEM homologs. The amino acid sequences of these proteins are different from other lectins but are closely related to the Class I mannosidases (family 47 glycosidases). EDEM2 is one of the EDEM homologs. Overexpression of EDEM2 accelerates the degradation of misfolded alpha1-antitrypsin, indicating that the protein is involved in ERAD.

Synonym: bA4204.1,C20orf31,C20orf49,UNQ573/PRO1135

Molekulargewicht: 54 kDa