EpCAM Protein (His tag)

Produktnummer ABIN7321140

Produktdetails

Target: EpCAM (EPCAM) (Epithelial Cell Adhesion Molecule (EPCAM))

Protein-Typ: Recombinant

Spezies: Ratte

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses EpCAM Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Rat EpCAM/TROP-1 Protein (His Tag)

Sequenz: Met1-Thr266

Produktmerkmale: A DNA sequence encoding the rat EPCAM (O55159) (Met1-Thr266) was expressed, fused with a polyhistidine tag at the C-terminus.

Reinheit: > 97 % as determined by SDS-PAGE

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: EpCAM (EPCAM) (Epithelial Cell Adhesion Molecule (EPCAM))

Andere Bezeichnung: EpCAM/TROP-1 (EPCAM Produkte)

Synonyme: DIAR5 Protein, EGP-2 Protein, EGP314 Protein, EGP40 Protein, ESA Protein, HNPCC8 Protein, KS1/4 Protein, KSA Protein, M4S1 Protein, MIC18 Protein, MK-1 Protein, TACSTD1 Protein, TROP1 Protein, ECS-1 Protein, ECS1 Protein, ESA1 Protein, M17S1 Protein, EGP Protein, Ep-CAM Protein, sb:cb6 Protein, tacstd Protein, wu:fj17g02 Protein, zgc:110304 Protein, zgc:77119 Protein, tacstd1 Protein, MGC80540 Protein, EPCAM Protein, egp Protein, ksa Protein, m4s1 Protein, mk-1 Protein, cd326 Protein, egp40 Protein, mic18 Protein, trop1 Protein, ep-cam Protein, hegp-2 Protein, co17-1a Protein, ga733-2 Protein, CD326 Protein, Egp314 Protein, EpCAM1 Protein, GA733-2 Protein, Ly74 Protein, Tacsd1 Protein, Tacstd1 Protein, gp40 Protein, epithelial cell adhesion molecule Protein, flotillin 2 Protein, epithelial cell adhesion molecule S homeolog Protein, EPCAM Protein, FLOT2 Protein, epcam Protein, epcam.S Protein, Epcam Protein

Hintergrund:

Background: Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type â… transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Synonym: EPCAM;Tacstd1

Molekulargewicht: 29.2 kDa

UniProt: O55159