EPHA1 Protein (His tag)

Produktnummer ABIN7195579

Produktdetails

Target: EPHA1 (Ephrin Type A Receptor 1 (EPHA1))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses EPHA1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse EphA1 Protein (His Tag)(Active)

Sequenz: Met 1-Glu 548

Produktmerkmale: A DNA sequence encoding the extracellular domain of mouse EPHA1 (Q60750) (Met 1-Glu 548) was expressed, with a C-terminal polyhistidine tag.

Reinheit: > 97 % as determined by SDS-PAGE

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by its binding ability in a functional ELISA. Immobilized mouse EPHA1-His at 10 μg/ml (100 μl/well) can bind mouse EFNA1-Fc ), The EC50 of mouse EFNA1-Fc is 21.3-49.8 ng/ml.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: EPHA1 (Ephrin Type A Receptor 1 (EPHA1))

Andere Bezeichnung: EphA1 (EPHA1 Produkte)

Synonyme: EPH Protein, EPHT Protein, EPHT1 Protein, 5730453L17Rik Protein, AL033318 Protein, Eph Protein, Esk Protein, EPHA9 Protein, EPH receptor A1 Protein, Eph receptor A1 Protein, EPHA1 Protein, Epha1 Protein

Hintergrund:

Background: EPHA1 or EPH receptor A1 belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. An important role of Eph receptors and their ligands ephrins is to mediate cell-contact-dependent repulsion. Eph receptors and ephrins also act at boundaries to channel neuronal growth cones along specific pathways, restrict the migration of neural crest cells, and via bidirectional signaling prevent intermingling between hindbrain segments. Eph receptors and ephrins can also trigger an adhesive response of endothelial cells and are required for the remodeling of blood vessels. Eph receptors and ephrins have emerged as key regulators of the repulsion and adhesion of cells that underlie the establishment, maintainence, and remodeling of patterns of cellular organization. The ephrins and Eph receptors are implicated as positional labels that may guide the development of neural topographic maps.

Synonym: 5730453L17Rik,AL033318,Eph,Esk

Molekulargewicht: 58.6 kDa

UniProt: Q60750