ECE1 Protein (His tag)

Produktnummer ABIN7319626

Produktdetails

Target: ECE1 (Endothelin-Converting Enzyme 1 (ECE1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses ECE1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human ECE1 Protein (His Tag)

Sequenz: Gln90-Trp770

Produktmerkmale: Recombinant Human Endothelin-converting Enzyme 1 is produced by our Mammalian expression system and the target gene encoding Gln90-Trp770 is expressed with a 8His tag at the N-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: ECE1 (Endothelin-Converting Enzyme 1 (ECE1))

Andere Bezeichnung: ECE1 (ECE1 Produkte)

Synonyme: ECE Protein, Ece Protein, AW322500 Protein, ECE-1 Protein, ECE-1a Protein, ECE-1b Protein, ECE-1d Protein, ece1 Protein, MGC52874 Protein, MGC130791 Protein, fd11b07 Protein, wu:fd11b07 Protein, zgc:154079 Protein, endothelin converting enzyme 1 Protein, endothelin converting enzyme like 1 Protein, endothelin converting enzyme 1 L homeolog Protein, endothelin-converting enzyme 1 Protein, Endothelin-converting enzyme 1 Protein, ECE1 Protein, ECEL1 Protein, Ece1 Protein, ece1.L Protein, Za10_0551 Protein, Arch_0474 Protein, Closa_0961 Protein, Odosp_0578 Protein, Bacsa_1787 Protein, Weevi_2017 Protein, Fluta_3444 Protein, Sphch_2390 Protein, ece1 Protein

Hintergrund:

Background: Endothelin-Converting Enzyme-1 (ECE-1) is a single-pass type I I transmembrane (TM) protein with a short cytoplasmic tail and a large ectodomain. ECE-1 is a zinc protease of the neprilysin (NEP) family, which also includes ECE-2, PEX, XCE, DINE, and Kell, and several NEP-like proteins. It is widely expressed and has several alternatively spliced forms that differ in their TM domain or cytoplasmic tail. All isoforms of ECE-1 are expressed in umbilical vein endothelial cells, polynuclear neutrophils, fibroblasts, atrium cardiomyocytes and ventricles. Endothelin-converting enzyme-1 is involved in the proteolytic processing of Endothelin-1 (EDN1), Endothelin-2 (EDN2), and Endothelin-3 (EDN3) to biologically active peptides. Defects in ECE1 are a cause of Hirschsprung disease, cardiac defects and autonomic dysfunction (HSCRCDAD). It is a form of Hirschsprung disease with skip-lesions defects, craniofacial abnormalities and other dysmorphic features, and autonomic dysfunction.

Synonym: Endothelin-converting enzyme 1, ECE-1

Molekulargewicht: 78.8 kDa

UniProt: P42892

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling