ENPP2 Protein (AA 49-863) (His tag)

Produktnummer ABIN7195473

Produktdetails

Target: ENPP2 (Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2))

Protein-Typ: Recombinant

Proteineigenschaft: AA 49-863

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses ENPP2 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Autotaxin/ENPP2 Protein (aa 49-863, His Tag)

Sequenz: Asp 49-Ile 863

Produktmerkmale: A DNA sequence encoding the mature form of human ENPP2 (AAH34961.1) (Asp 49-Ile 863) was expressed, with a polyhistidine tag at the N-terminus.

Reinheit: > 88 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: ENPP2 (Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2))

Andere Bezeichnung: Autotaxin/ENPP2 (ENPP2 Produkte)

Synonyme: ATX Protein, ATX-X Protein, AUTOTAXIN Protein, LysoPLD Protein, NPP2 Protein, PD-IALPHA Protein, PDNP2 Protein, Npps2 Protein, PD-Ialpha Protein, Pdnp2 Protein, MGC132047 Protein, atx Protein, zgc:63550 Protein, autotaxin Protein, enpp2 Protein, enpp2a Protein, enpp2b Protein, ectonucleotide pyrophosphatase/phosphodiesterase 2 Protein, ectonucleotide pyrophosphatase/phosphodiesterase 2 L homeolog Protein, ectonucleotide pyrophosphatase/phosphodiesterase 2 S homeolog Protein, ENPP2 Protein, Enpp2 Protein, enpp2 Protein, enpp2.L Protein, enpp2.S Protein

Hintergrund:

Background: ENPP2 (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2), also referred as Autotaxin, is a secreted enzyme encoded by the ENPP2 gene. This gene product stimulates the motility of tumor cells, has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The Autotaxin protein is important for generating the lipid signaling molecule lysophosphatidic acid (LPA), which is a potent mitogen, which facilitates cell proliferation and migration, neurite retraction, platelet aggregation, smooth muscle contraction, actin stress formation and cytokine and chemokine secretion. ATX has been found to catalyze the formation of cyclic phosphatidic acid (cPA), which have antitumor role by antimitogenic regulation of cell cycle, inhibition of cancer invasion and metastasis. LPA receptors and ATX are upregulated in numerous cancer cell types and show expression patterns that correlate with tumor cell invasiveness. Thus, Autotaxin has recently emerged as an attractive target for the development of anti-cancer chemotherapeutics. In addition, Serum ATX activity was found to be enhanced in relation to hepatic fibrosis in chronic liver disease due to hepatitis virus C infection.

Synonym: ATX, ATXFLJ26803, ATX-X, Autotaxin, autotaxin-t, EC 3.1.4.39, ectonucleotide pyrophosphatase/phosphodiesterase 2,E-NPP 2, ENPP2, LysoPLD, NPP2, PD-IALPHA, PDNP2, PDNP2NPP2

Molekulargewicht: 96 kDa