DNASE1 Protein (His tag)

Produktnummer ABIN7317198

Produktdetails

Target: DNASE1 (Deoxyribonuclease I (DNASE1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses DNASE1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human DNASE1/Deoxyribonuclease I/DNL1 Protein (His Tag)

Sequenz: Met 1-Lys282

Produktmerkmale: A DNA sequence encoding the human DNASE1 (P24855) (Met1-Lys282) was expressed with a polyhistidine tag at the C-terminus.

Reinheit: > 85 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: DNASE1 (Deoxyribonuclease I (DNASE1))

Andere Bezeichnung: DNASE1/Deoxyribonuclease I/DNL1 (DNASE1 Produkte)

Synonyme: LOC397802 Protein, DNL1 Protein, DRNI Protein, AI788650 Protein, DNaseI Protein, Dnl1 Protein, dnase1-A Protein, zgc:92440 Protein, DNase I Protein, deoxyribonuclease 1 Protein, deoxyribonuclease I Protein, deoxyribonuclease I L homeolog Protein, Deoxyribonuclease I Protein, endA Protein, LOC397802 Protein, DNASE1 Protein, Dnase1 Protein, dnase1.L Protein, dnase1 Protein, CpipJ_CPIJ011184 Protein, CpipJ_CPIJ011185 Protein, CpipJ_CPIJ011186 Protein, CpipJ_CPIJ011187 Protein, CpipJ_CPIJ011190 Protein, CpipJ_CPIJ017803 Protein, Desal_1409 Protein, MPET_RS05255 Protein, METEV_RS02275 Protein, Plabr_0631 Protein

Hintergrund:

Background: DNase1, also known as deoxyribonuclease I and DNL1, is a member of the DNase family. DNaseI is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides. DNaseI binds to the cytoskeletal protein actin. It binds actin monomers with very high (sub-nanomolar) affinity and actin polymers with lower affinity. Mutations in DNase1 gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. DNase1 is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity.

Synonym: DNL1,DRNI

Molekulargewicht: 30.7 kDa

UniProt: P24855