C12orf53 Protein (Fc Tag)

Produktnummer ABIN7317278

Produktdetails

Target: C12orf53 (Chromosome 12 Open Reading Frame 53 (C12orf53))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses C12orf53 Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Recombinant Human C12orf53 Protein (Fc Tag)

Sequenz: Met 1-Pro178

Produktmerkmale: A DNA sequence encoding the human C12orf53 (Q8IYJ0-1) (Met1-Pro178) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

Reinheit: > 96 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: C12orf53 (Chromosome 12 Open Reading Frame 53 (C12orf53))

Andere Bezeichnung: C12orf53 (C12orf53 Produkte)

Synonyme: C12orf53 Protein, PANP Protein, leda-1 Protein, PILR alpha associated neural protein Protein, PIANP Protein

Hintergrund:

Background: C12orf53 is mainly expressed in adult brain and cerebellum. It also can be detected in fetal brain and virtually no expression in spleen, heart, kidney, liver and dorsal ganglion relative to brain. C12orf53 acts as a ligand for PILRA in neural tissues, where it may be involved in immune regulation. Chromosome 12 encodes over 1,100 genes within 132 million bases. A number of skeletal deformities are linked to chromosome 12 including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Noonan syndrome, which includes heart and facial developmental defects among the primary symptoms, is caused by a mutant form of PTPN11 gene product, SH-PTP2. Chromosome 12 is also home to a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC class I interaction.

Synonym: C12orf53,leda-1,LEDA1,PANP,UNQ828/PRO1755

Molekulargewicht: 42.3 kDa