CCL8 Protein (His tag)

Produktnummer ABIN7317123

Produktdetails

Target: CCL8 (Chemokine (C-C Motif) Ligand 8 (CCL8))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Hefe

Aufreinigungstag / Konjugat: Dieses CCL8 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human CCL8/MCP-2 Protein (Yeast, His Tag)

Sequenz: Gln24-Pro99

Produktmerkmale: A DNA sequence encoding the human CCL8 (NP_005614.2) (Gln24-Pro99) was expressed with a polyhistidine tag at the C-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: CCL8 (Chemokine (C-C Motif) Ligand 8 (CCL8))

Andere Bezeichnung: CCL8/MCP-2 (CCL8 Produkte)

Synonyme: HC14 Protein, MCP-2 Protein, MCP2 Protein, SCYA10 Protein, SCYA8 Protein, 1810063B20Rik Protein, AB023418 Protein, Mcp2 Protein, Scya8 Protein, C-C motif chemokine ligand 8 Protein, chemokine (C-C motif) ligand 8 Protein, C-C motif chemokine 8 Protein, monocyte chemoattractant protein-2 precursor Protein, CCL8 Protein, Ccl8 Protein, LOC101119572 Protein, MCP-2 Protein

Hintergrund:

Background: Chemokines are a family of small chemotactic cytokines, or proteins secreted by cells. Chemokines share the same structure similarities such as small size, and the presence of four cysteine residues in conserved locations in order to form their 3-dimensional shape. Some of the chemokines are considered pro-inflammatory which can be induced to recruit cells of the immune system to a site of infection during an immune response, while others are considered homeostatic and are implied in controlling the migration of cells during normal processes of tissue maintenance and development. There are four members of the chemokine family: C-C kemokines, C kemokines, CXC kemokines and CX3C kemokines. The C-C kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands-1 to 28. Chemokine ligand 8 (CCL8), also known as monocyte chemoattractant protein 2 (MCP-2), is a small cytokine belonging to the C-C chemokine family. CCL8 functions to activate different immune cells, including mast cells, eosinophils and basophils which are involved in allergic responses, monocytes, and T cells and NK cells which are involved in the inflammatory response. CCL8's ability achieves by binding to different cell surface receptors termed chemokine receptors including CCR1, CCR2B and CCR5. It has been reported that CCL8 is a potent inhibitor of HIV-1 by virtue of its binding to CCR5 which is one of the major co-receptors for HIV-1.

Synonym: C-C Motif Chemokine 8, HC14, Monocyte Chemoattractant Protein 2, Monocyte Chemotactic Protein 2, MCP-2, Small-Inducible Cytokine A8, CCL8, MCP2, SCYA10, SCYA8,HC14

Molekulargewicht: 10.3 kDa

NCBI Accession: NP_005614