CRABP2 Protein (His tag)

Produktnummer ABIN7320242

Produktdetails

Target: CRABP2 (Cellular Retinoic Acid Binding Protein 2 (CRABP2))

Protein-Typ: Recombinant

Spezies: Maus

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses CRABP2 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse CRABP2 Protein (His Tag)

Sequenz: Pro 2-Glu 138

Produktmerkmale: A DNA sequence encoding the mouse CRABP2 (P22935) (Pro 2-Glu 138) was expressed, with a polyhistide tag at the N-terminus.

Reinheit: > 96 % as determined by SDS-PAGE

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: CRABP2 (Cellular Retinoic Acid Binding Protein 2 (CRABP2))

Andere Bezeichnung: CRABP2 (CRABP2 Produkte)

Synonyme: crabp Protein, crabp2-A Protein, xCRABP Protein, xCRABP-b Protein, cb432 Protein, cb434 Protein, crabp2 Protein, sb:cb434 Protein, wu:fc51a11 Protein, zgc:110496 Protein, CRABP2 Protein, rbp6 Protein, MGC89469 Protein, crabp-ii Protein, CRABP-II Protein, RBP6 Protein, AI893628 Protein, Crabp-2 Protein, CrabpII Protein, im:7136989 Protein, cellular retinoic acid binding protein 2 L homeolog Protein, cellular retinoic acid binding protein 2, a Protein, cellular retinoic acid binding protein 2 Protein, cellular retinoic acid binding protein II Protein, cellular retinoic acid binding protein 2, b Protein, crabp2.L Protein, crabp2a Protein, CRABP2 Protein, crabp2 Protein, Crabp2 Protein, crabp2b Protein

Hintergrund:

Background: Cellular retinoic acid-binding protein 2, also known as Cellular retinoic acid-binding protein II, CRABP-II and CRABP2, is a protein which belongs to the calycin superfamily and Fatty-acid binding protein (FABP) family. Cellular retinoic acid binding proteins (CRABP) are low molecular weight proteins whose precise function remains unknown. The predicted amino acid sequences of human CRABP1 and CRABP2 demonstrated a 99.3% and 93.5% identity to mouse CRABP1 and CRABP2, respectively. CRABP2 forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. Expression of CRABP2, but not CRABP1 mRNA, was markedly increased (greater than 15-fold) by retinoic acid treatment of fibroblasts cultured from human skin, whereas no significant induction of CRABP2 mRNA was observed in human lung fibroblasts. CRABP2 transports retinoic acid to the nucleus. It regulates the access of retinoic acid to the nuclear retinoic acid receptors. CRABP2 is necessary for elastin induction by All-trans retinoic acid (ATRA) in MRC-5 cells. It is expressed at low levels in emphysema fibroblasts. This alteration in the retinoic acid signalling pathway in lung fibroblasts may contribute to the defect of alveolar repair in human pulmonary emphysema.

Synonym: AI893628;Crabp-2;CrabpII

Molekulargewicht: 17.1 kDa

UniProt: P22935