CDC37 Protein (GST tag)

Produktnummer ABIN7317809

Produktdetails

Target: CDC37 (Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Aufreinigungstag / Konjugat: Dieses CDC37 Protein ist gelabelt mit GST tag.

Verwendungszweck: Recombinant Human CDC37/CDC37A Protein (GST Tag)

Sequenz: Met 1-Val 378

Produktmerkmale: A DNA sequence encoding the full length of human CDC37 (NP_008996.1) (Met 1-Val 378) was fused with the GST tag at the C-terminus.

Reinheit: > 85 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 50 mM Tris, 100 mM NaCl, 0.5 mM GSH, 0.5 mM PMSF, 10 % glycerol, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: CDC37 (Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37))

Andere Bezeichnung: CDC37/CDC37A (CDC37 Produkte)

Synonyme: CG12019 Protein, CPDR-1 Protein, CPDR-2 Protein, DROCPDR Protein, Dmel\\CG12019 Protein, E(sev)3B Protein, cdc37 Protein, Afu4g10010 Protein, P50CDC37 Protein, p50 Protein, p50Cdc37 Protein, CG12019 gene product from transcript CG12019-RA Protein, cell division cycle 37 homolog Protein, Hsp90 co-chaperone Cdc37 Protein, Cdc37p Protein, cell division cycle 37 Protein, Cdc37 Protein, cdc37 Protein, AFUA_4G10010 Protein, CDC37 Protein

Hintergrund:

Background: CDC37 is a protein that is expressed in proliferative zones during embryonic development and in adult tissues, consistent with a positive role in proliferation and is required for cell division in budding yeast. CDC37 is though to play an important role in the establishment of signaling pathways controlling cell proliferation through targeting intrinsically unstable oncoprotein kinases such as Cdk-4, Raf-1, and src to the molecular chaperone Hsp90. Decreased Hsp90 expression can reduce the levels of microtubule-associated protein tau, whose overexpression may induce many diseases. CDC37 is considered as a co-chaperone that is classified to Hsp90's accessory proteins. It has been reported that suppression of Cdc37 destabilized tau, leading to its clearance, whereas cdc37 overexpression preserved tau.Cdc37 was found to co-localize with tau in neuronal cells and to physically interact with tau from human brain. Moreover, Cdc37 levels significantly increased with age.

Synonym: P50CDC37

Molekulargewicht: 70.7 kDa

NCBI Accession: NP_008996