CD5 Protein (CD5) (AA 24-370) (His tag)

Produktnummer ABIN7320723

Produktdetails

Target: CD5

Protein-Typ: Recombinant

Proteineigenschaft: AA 24-370

Spezies: Maus

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses CD5 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse CD5 Protein (aa 24-370, His Tag)

Sequenz: Gln24-Asn370

Produktmerkmale: Recombinant Mouse T-Cell Surface Glycoprotein CD5 is produced by our Mammalian expression system and the target gene encoding Gln24-Asn370 is expressed with a 6His tag at the C-terminus.

Reinheit: > 95 % as determined by SDS-PAGE

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: CD5

Andere Bezeichnung: CD5 (CD5 Produkte)

Synonyme: CD5 Protein, Ly-1 Protein, Ly-12 Protein, Ly-A Protein, Lyt-1 Protein, LEU1 Protein, T1 Protein, CD5 molecule Protein, CD5 antigen Protein, CD5 molecule like Protein, Cd5 molecule Protein, CD5 Protein, Cd5 Protein, CD5L Protein

Hintergrund:

Background: CD5 is a transmembrane glycoprotein of the conserved scavenger receptor cysteine-rich (SRCR) superfamily and expressed on thymocytes, peripheral T cells and a subset of B cells (B1-a). Moreover, CD5 also was found expressed in small lymphocytic lymphoma, hairy cell leukaemia and mantle cell lymphoma cells. The long cytoplasmic tail of CD5 has no intrinsic enzymatic activity, but contains four tyrosine phosphorylation sites, including an immunoreceptor tyrosine-based (ITAM)-like motif (pseudo-ITAM) and an immunoreceptor tyrosine-based inhibitory (ITIM)-like motif (pseudo-ITIM), as well as multiple potential serine and threonine phosphorylation sites. It physically associates with the T cell antigen receptor (TCR) and B cell antigen receptor (BCR), where it negatively modulates the activation and differentiation signals transduced by these receptors. CD5 also plays an important role in protection from activation-induced cell death and in the recognition of pathogen associated molecular patterns (PAMPS) present on fungal surfaces.

Synonym: T-cell surface glycoprotein CD5, CD5, CD5 antigen, CD5 antigen (p56-62), CD5 Molecule, LEU1T-cell surface glycoprotein CD5, Lymphocyte antigen T1,Leu-1, T1, Ly-1

Molekulargewicht: 38.9 kDa

NCBI Accession: NP_031676