CPB2 Protein (His tag)

Produktnummer ABIN7317552

Produktdetails

Target: CPB2 (Carboxypeptidase B2 (Plasma) (CPB2))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses CPB2 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Carboxypeptidase B2/CPB2 Protein (His Tag)

Sequenz: Met 1-Val 423

Produktmerkmale: A DNA sequence encoding the human CPB2 (NP_001863.2) extracellular domain (Met 1-Val 423) was expressed, fused with a polyhistidine tag at the C-terminus.

Reinheit: > 97 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: CPB2 (Carboxypeptidase B2 (Plasma) (CPB2))

Andere Bezeichnung: Carboxypeptidase B2/CPB2 (CPB2 Produkte)

Synonyme: CPU Protein, PCPB Protein, TAFI Protein, 1110032P04Rik Protein, 4930405E17Rik Protein, AI255929 Protein, CPR Protein, Cpu Protein, pCPB Protein, zgc:112493 Protein, carboxypeptidase B2 Protein, carboxypeptidase B2 (plasma) Protein, CPB2 Protein, Cpb2 Protein, cpb2 Protein

Hintergrund:

Background: Carboxypeptidase B2, also known as Carboxypeptidase U, Thrombin-activable fibrinolysis inhibitor, Plasma carboxypeptidase B, CPB2, is a secreted protein which belongs to the peptidase M14 family. Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). CPB2 is activated by thrombin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. CPB2 is synthesized by the liver and circulates in the plasma as a plasminogen-bound zymogen. When it is activated by proteolysis at residue Arg92 by the thrombin / thrombomodulin complex. CPB2 cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. CPB2 exhibits carboxypeptidase activity and activated CPB2 reduces fibrinolysis by removing the fibrin C-terminal residues that are important for the binding and activation of plasminogen.

Synonym: Carboxypeptidase B2, Carboxypeptidase U, CPU, Plasma Carboxypeptidase B, pCPB, Thrombin-Activable Fibrinolysis Inhibitor, TAFI, CPB2

Molekulargewicht: 47.4 kDa

NCBI Accession: NP_001863

Pathways: Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis