CALML3 Protein (His tag)

Produktnummer ABIN7194535

Produktdetails

Target: CALML3 (Calmodulin Like Protein 3 (CALML3))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses CALML3 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human CALML3 Protein (His Tag)

Sequenz: Met 1-Lys 149

Produktmerkmale: A DNA sequence encoding the human CALML3 (P27482) (Met 1-Lys 149) was expressed, with a polyhistide tag at the N-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: CALML3 (Calmodulin Like Protein 3 (CALML3))

Andere Bezeichnung: CALML3 (CALML3 Produkte)

Synonyme: CLP Protein, 2310068O22Rik Protein, AI326174 Protein, CALM3 Protein, CCM1 Protein, calmodulin like 3 Protein, calmodulin-like 3 Protein, CALML3 Protein, Calml3 Protein

Hintergrund:

Background: Calmodulin-like protein 3 (CALML3) is similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinity, to cellular substrates. Calmodulin-like protein 3 (CALML3) is a tumor-sensitive protein specifically expressed in normal epithelial cells but downregulated in tumorigenesis. Downregulation of the protein is an early event in breast cancer development. One of the most pressing questions raised by the discovery of CLP/CALML3 is that of its potential targets. Although it is 85 % identical to human calmodulin, the distinct properties of CLP suggest that it has specific targets or targets that only partially overlap with those of calmodulin. Research has identified the unconventional myosin-10 (Myo10) as a specific target of CALML3. The discovery of Myo10 as a specific target of CALML3 is highly significant and suggests multiple lines of further research such as investigations of the Ca2+ regulation of Myo10 and the role of the loss of CLP in epithelial differentiation, adhesion, and cancer. Cells expressing CALML3 displayed a striking increase in the number and length of myosin-10-positive filopodia and showed increased mobility in a wound healing assay.

Synonym: CLP

Molekulargewicht: 18.7kDa

UniProt: P27482

Pathways: Phototransduction