CLEC2D Protein (Fc Tag)

Produktnummer ABIN7321164

Produktdetails

Target: CLEC2D (C-Type Lectin Domain Family 2, Member D (CLEC2D))

Protein-Typ: Recombinant

Spezies: Ratte

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses CLEC2D Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Recombinant Rat CLEC2D/OCIL Protein (Fc Tag)

Sequenz: Lys98-Leu233

Produktmerkmale: A DNA sequence encoding the rat CLEC2D (NP_569086.1) (Lys98-Leu233) was expressed with Fc region of human IgG1 at the N-terminus.

Reinheit: (76.7+14.8) % as determined by SDS-PAGE

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: CLEC2D (C-Type Lectin Domain Family 2, Member D (CLEC2D))

Andere Bezeichnung: CLEC2D/OCIL (CLEC2D Produkte)

Synonyme: CLAX Protein, LLT1 Protein, OCIL Protein, Clr-b Protein, Clrb Protein, Ocil Protein, Clec2d5 Protein, CLEC2D Protein, C-type lectin domain family 2 member D Protein, C-type lectin domain family 2, member d Protein, C-type lectin domain family 2, member D Protein, CLEC2D Protein, Clec2d Protein

Hintergrund:

Background: Lectin-like transcript 1 (LLT1) encoded by CLEC2D gene is a C-type lectin-like molecule interacting with human CD161 (NKR-P1A) receptor expressed by natural killer cells and subsets of T cells. CLEC2D transcripts were detected primarily in hematopoietic cell lines and were found to be co-induced by the same activation signals. Although very low amounts of putative soluble CLEC2D protein isoforms could be produced by transfectants, CLEC2D isoforms 2 and 4 were efficiently expressed. CLEC2D uses gene splicing to generate protein isoforms that are structurally distinct and that have different biological activities. Prostate cancer is the most common type of cancer diagnosed and the second leading cause of cancer-related death in American men. Natural Killer (NK) cells are the first line of defense against cancer and infections. NK cell function is regulated by a delicate balance between signals received through activating and inhibitory receptors. Previously, we identified Lectin-like transcript-1 (LLT1/OCIL/CLEC2D) as a counter-receptor for the NK cell inhibitory receptor NKRP1A (CD161). Interaction of LLT1 expressed on target cells with NKRP1A inhibits NK cell activation.

Synonym: CLEC2D

Molekulargewicht: 44 kDa

NCBI Accession: NP_569086

Pathways: Regulation of Leukocyte Mediated Immunity