BAMBI Protein (His tag)
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- Target Alle BAMBI Proteine anzeigen
- BAMBI (BMP and Activin Membrane-Bound Inhibitor Homolog (BAMBI))
- Protein-Typ
- Recombinant
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Spezies
- Human
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses BAMBI Protein ist gelabelt mit His tag.
- Verwendungszweck
- Recombinant Human BAMBI Protein (His Tag)
- Sequenz
- Met 1-Ala 152
- Produktmerkmale
- A DNA sequence encoding the human BAMBI extracellular domain (NP_036474.1) (Met 1-Ala 152) was expressed, fused with a C-terminal polyhistidine tag.
- Reinheit
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin-Niveau
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Top Product
- Discover our top product BAMBI Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Lagerung
- 4 °C,-20 °C,-80 °C
- Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- BAMBI (BMP and Activin Membrane-Bound Inhibitor Homolog (BAMBI))
- Andere Bezeichnung
- BAMBI (BAMBI Produkte)
- Synonyme
- NMA Protein, bambi Protein, nma Protein, BAMBI Protein, Zfnma Protein, cb998 Protein, fc44c12 Protein, id:ibd5020 Protein, wu:fc44c12 Protein, wu:fe01e03 Protein, 2610003H06Rik Protein, bambi-A Protein, zgc:91871 Protein, BMP and activin membrane bound inhibitor Protein, BMP and activin membrane-bound inhibitor homolog Protein, BMP and activin membrane-bound inhibitor Protein, BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a Protein, BMP and activin membrane-bound inhibitor L homeolog Protein, BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) b Protein, BAMBI Protein, bambi Protein, bambia Protein, Bambi Protein, LOC724378 Protein, LOC100647353 Protein, bambi.L Protein, bambib Protein
- Hintergrund
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Background: BMP and activin membrane-bound inhibitor (BAMBI) is a transmembrane glycoprotein that is a pseudoreceptor of type 1 receptors. BAMBI structurally lacks intracellular serine/ threonine kinase domain but with an extracellular domain and a short cytoplasmic region that share sequence similarities with type 1 receptors, whose members have functions in signal transduction in various developing and pathological processes. BAMBI competes with the type 1 receptor, a receptor of the transforming growth factor-beta (TGF-beta), through functioning as negative regulators of TGF-beta by limiting the signaling range of the TGF-beta family during early embryogenesis. The expression of BAMBI can be induced by accumulated beta-catenin and BMP. The expression level of BAMBI was found aberrantly elevated in most colorectal and hepatocellular carcinomas relative to the corresponding non-cancerous tissues. It suggestes that beta-catenin and TGF-beta interfere growth arrest by inducing the expression of BAMBI, and this may contribute to colorectal and hepatocellular tumorigenesis.
Synonym: NMA
- Molekulargewicht
- 16.1 kDa
- NCBI Accession
- NP_036474
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