ALDH3A1 Protein (His tag)

Produktnummer ABIN7317365

Produktdetails

Target: ALDH3A1 (Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Aufreinigungstag / Konjugat: Dieses ALDH3A1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human ALDH3A1 Protein (Baculovirus, His Tag)

Sequenz: Met 1-His 453

Produktmerkmale: A DNA sequence encoding the human ALDH3A1 (AAH04370.1) (Met 1-His 453) was fused with a polyhistidine tag at the N-terminus.

Reinheit: > 90 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: ALDH3A1 (Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1))

Andere Bezeichnung: ALDH3A1 (ALDH3A1 Produkte)

Synonyme: ALDC Protein, ALDH-E1 Protein, ALDH1 Protein, ALDH11 Protein, PUMB1 Protein, RALDH1 Protein, ALDH3 Protein, ALDHIII Protein, Ahd-4 Protein, Ahd4 Protein, Aldh Protein, Aldh3 Protein, AHDC Protein, Ahd-c Protein, aldehyde dehydrogenase 1 family member A1 Protein, aldehyde dehydrogenase 3 family member A1 Protein, aldehyde dehydrogenase Protein, aldehyde dehydrogenase, dimeric NADP-preferring Protein, aldehyde dehydrogenase family 3, subfamily A1 Protein, aldehyde dehydrogenase 3 family, member A1 Protein, ALDH1A1 Protein, ALDH3A1 Protein, OE_RS03630 Protein, LOC100077088 Protein, CLL_A1665 Protein, LOC100281700 Protein, LOC100285809 Protein, Aldh3a1 Protein

Hintergrund:

Background: Aldehyde dehydrogenase 3A1 (ALDH3A1) is a metabolic enzyme that catalyzes the oxidation of various aldehydes. Certain types of epithelial tissues in mammals, especially those continually exposed to environmental stress (e.g., corneal epithelium), express ALDH3A1 at high levels and its abundance in such tissues is perceived to help to maintain cellular homeostasis under conditions of oxidative stress. Metabolic as well as non-metabolic roles for ALDH3A1 have been associated with its mediated resistance to cellular oxidative stress. Aldehyde dehydrogenase 1A1 (ALDH1A1) and ALDH3A1 are corneal crystallins. They protect inner ocular tissues from ultraviolet radiation (UVR)-induced oxidative damage through catalytic and non-catalytic mechanisms. Additionally, ALDH3A1 has been postulated to play a regulatory role in the corneal epithelium based on several studies that report an inverse association between ALDH3A1 expression and corneal cell proliferation. Aldehyde dehydrogenase 3A1 (ALDH3A1) plays an important role in many cellular oxidative processes, including cancer chemoresistance, by metabolizing activated forms of oxazaphosphorine drugs such as cyclophosphamide (CP) and its analogues, such as mafosfamide (MF), ifosfamide (IFM), and 4-hydroperoxycyclophosphamide (4-HPCP). Compounds that can selectively target ALDH3A1 could permit delineation of its roles in these processes and could restore chemosensitivity in cancer cells that express this isoenzyme. ALDH3A1 may act to protect corneal cells against cellular oxidative damage by metabolizing toxic lipid peroxidation products (e.g., 4-HNE), maintaining cellular GSH levels and redox balance, and operating as an antioxidant.

Synonym: Aldehyde dehydrogenase, dimeric NADP-preferring,ALDH3,ALDH3A1,Aldehyde dehydrogenase family 3 member A1,Aldehyde dehydrogenase 3,ALDHIII,ALDH3A1

Molekulargewicht: 52.6 kDa