ADK Protein (GST tag,His tag)
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- Target Alle ADK Proteine anzeigen
- ADK (Adenosine Kinase (ADK))
- Protein-Typ
- Recombinant
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Spezies
- Human
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Quelle
- Baculovirus infected Insect Cells
- Aufreinigungstag / Konjugat
- Dieses ADK Protein ist gelabelt mit GST tag,His tag.
- Verwendungszweck
- Recombinant Human ADK Protein (His & GST Tag)
- Sequenz
- Met 1-His 345
- Produktmerkmale
- A DNA sequence encoding the human ADK isoform short (AAH03568.1) (Met 1-His 345) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- Reinheit
- > 90 % as determined by reducing SDS-PAGE.
- Endotoxin-Niveau
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product ADK Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Frozen, Liquid
- Buffer
- Supplied as sterile 50 mM Tris, 100 mM NaCl, pH 8.0, 10 % glycerol, 0.3 mM DTT
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Target
- ADK (Adenosine Kinase (ADK))
- Andere Bezeichnung
- ADK (ADK Produkte)
- Synonyme
- AK Protein, ADK Protein, DDBDRAFT_0186795 Protein, DDBDRAFT_0230174 Protein, DDB_0186795 Protein, DDB_0230174 Protein, ATPADK1 Protein, F3G5.4 Protein, F3G5_4 Protein, adenosine kinase Protein, adk Protein, 2310026J05Rik Protein, 5033405D03Rik Protein, AI255373 Protein, AI987814 Protein, Ak Protein, adenosine kinase Protein, ATP:adenosine 5'-phosphotransferase Protein, Adenosine kinase Protein, adenosine kinase S homeolog Protein, ADK Protein, adk Protein, Adk Protein, CNN02130 Protein, LOC5572668 Protein, CMU_026370 Protein, adk.S Protein
- Hintergrund
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Background: Adenosine kinase(ADK) belongs to the family of transferases. Adenosine kinase (ADK) is the key enzyme in adenosine metabolism and catalyzes ATP and adenosine into two products: ADP and AMP. Two isoforms of the enzyme adenosine kinase (ADK), which differ at their N-terminal ends, are found in mammalian cells. It has been shown that the two ADK isoforms differ only in their first exons and the promoter regions; hence they arise via differential splicing of their first exons with the other exons common to both isoforms. In adult brain, ADK is primarily present in astrocytes. Several lines of experimental evidence support a critical role of ADK in different types of brain injury associated with astrogliosis, which is also a prominent morphologic feature of temporal lobe epilepsy (TLE). It has been suggested that dysregulation of ADK in astrocytes is a common pathologic hallmark of TLE. Moreover, in vitro data suggest the existence of an additional layer of modulatory crosstalk between the astrocyte-based adenosine cycle and inflammation. ADK also contributes to CK homeostasis in vivo.
Synonym: AK
- Molekulargewicht
- 68 kDa
- Pathways
- Ribonucleoside Biosynthetic Process
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