PFKFB3 Protein (His tag)

Produktnummer ABIN7319866

Produktdetails

Target: PFKFB3 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses PFKFB3 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human PFKFB3 (N-6His)

Sequenz: Met1-His520

Produktmerkmale: Recombinant Human 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 is produced by our E.coli expression system and the target gene encoding Met1-His520 is expressed with a 6His tag at the N-terminus.

Reinheit: >95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 50 mM Tris-HCl, 50 mM KCl, 1 mM DTT, 0.1 mM EDTA, 20 % Glycerol, pH 8.0.

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Antigendetails

Target: PFKFB3 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3))

Andere Bezeichnung: PFKFB3 (PFKFB3 Produkte)

Synonyme: IPFK2 Protein, PFK2 Protein, E330010H22Rik Protein, iPFK-2 Protein, uPFK-2 Protein, PFKFB3 Protein, zgc:73257 Protein, wu:fc31e01 Protein, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Protein, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 S homeolog Protein, PFKFB3 Protein, Pfkfb3 Protein, pfkfb3.S Protein, pfkfb3 Protein, PTRG_09894 Protein, Tsp_06710 Protein

Hintergrund:

Background: Fructose-2,6-biphosphatase 3, also known as 6-phosphofructo-2-kinase or PFK2 or PFKFB3, involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls the activity of the enzymes phosphofructokinase 1 (PFK-1) and fructose 1,6-bisphosphatase (FBPase-1) to regulate glycolysis and gluconeogenesis. Highly phosphorylated PFKFB3 protein was found in human tumor cells, vascular endothelial cells, and smooth muscle cells. Because of its proto-oncogenic character, the PFK-2/FBPase-2 of the PFKFB3 gene is assumed to play a critical role in tumorigenesis. PFKFB3 also plays a crucial role in the progression of cancerous cells by enabling their glycolytic pathways even under severe hypoxic conditions, which makes it a potential target for cancer therapy.

Synonym: IPFK2, PFK2, iPFK-2, PFK/FBPase 3

Molekulargewicht: 61.8 kDa

UniProt: Q16875

Pathways: AMPK Signaling, Regulation of Carbohydrate Metabolic Process