SIGLEC7 Protein (Glu201Ala-Mutant, Gly120Ala-Mutant, Leu118Ala-Mutant) (Fc Tag)
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- Target Alle SIGLEC7 Proteine anzeigen
- SIGLEC7 (Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))
- Protein-Typ
- Recombinant
- Proteineigenschaft
- Glu201Ala-Mutant, Gly120Ala-Mutant, Leu118Ala-Mutant
- Spezies
- Human
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses SIGLEC7 Protein ist gelabelt mit Fc Tag.
- Verwendungszweck
- Human Siglec-7 / CD328 Protein, Fc (L118A, G120A, E201A) Tag (MALS verified)
- Sequenz
- Gln 19 - Leu 353
- Produktmerkmale
- Human Siglec-7, Fc (L118A, G120A, E201A) Tag is expressed from human 293 cells (HEK293). It contains AA Gln 19 - Leu 353 (Accession # Q9Y286-1).
- Reinheit
- >95 % as determined by SDS-PAGE.
- Endotoxin-Niveau
- Less than 0.01 EU per μg by the LAL method.
- Güteklasse
- MALS verified
- Top Product
- Discover our top product SIGLEC7 Protein
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- Applikationshinweise
- This protein carries a Fc (L118A, G120A, E201A) tag at the C-terminus. The protein has a calculated MW of 63.3 kDa. The protein migrates as 70-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. Mutations (L118A, G120A, E201A /EU number: L235A/G237A/E318A) in human immunoglobulin G1 (hIgG1) Fc strongly reduce binding of the Fc mutant to cell expressed FcγRs, resulting in an almost 4-fold reduction in ADCC compared to that of wild type human IgG1.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Buffer
- 25 mM MES, 150 mM NaCl
- Lagerung
- -20 °C
- Informationen zur Lagerung
- -20°C
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- Target
- SIGLEC7 (Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))
- Andere Bezeichnung
- Siglec-7 / CD328 (SIGLEC7 Produkte)
- Synonyme
- SIGLEC7 Protein, AIRM1 Protein, CD328 Protein, CDw328 Protein, D-siglec Protein, QA79 Protein, SIGLEC-7 Protein, SIGLEC19P Protein, SIGLECP2 Protein, p75 Protein, p75/AIRM1 Protein, sialic acid-binding Ig-like lectin 7 Protein, sialic acid binding Ig like lectin 7 Protein, LOC468976 Protein, SIGLEC7 Protein
- Hintergrund
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Synonyms: CDw328,D-siglec,A79 membrane protein,p75,Adhesion inhibitory receptor molecule 1, AIRM-1,
Siglec-7 is a member of the human CD33-related Siglec receptor. The extracellular region of Siglec-7 is characterized by an N-terminal V-set Ig domain that can bind sialic acid and two C2-set Ig domains. The cytoplasmic tail of Siglec-7 has one immune-receptor tyrosine-based inhibitory motif (ITIM) and one ITIM-like motif. Siglec-7 is considered as a sialic acid-dependent immunoreceptor with inhibitory potential and expressed predominantly on human NK cells, monocytes and a small subset of CD8+ T cells. - Molekulargewicht
- 63.3 kDa
- NCBI Accession
- NP_055200
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