Mouse IL-2 R beta&IL-2 R gamma Heterodimer Protein, Fc Tag&Fc Tag (MALS verified)
Sequenz
Ala 27 - Glu 240 (IL-2RB) & Trp 23 - Ala 263 (IL-2RG)
Produktmerkmale
Mouse IL-2RB&IL-2RG Heterodimer Protein, Fc Tag&Fc Tag (ILG-M5254) is expressed from human 293 cells (HEK293). It contains AA Ala 27 - Glu 240 (IL-2RB) & Trp 23 - Ala 263 (IL-2RG) (Accession # P16297-1 (IL-2RB) & P34902-1 (IL-2RG).
MALS verified
Spezies: Cynomolgus
Wirt: HEK-293 Cells
Recombinant
>95 % as determined by SDS-PAGE.
Applikationshinweise
Mouse IL-2RB&IL-2RG Heterodimer Protein, Fc Tag&Fc Tag is produced by co-expression of IL-2RB and IL-2RG, has a calculated MW of 51.5 kDa (IL-2RB) and 54.5 kDa (IL-2RG). Subunit IL-2RB is fused with a human IgG1 Fc tag at the C-terminus and subunit IL-2RG is fused with a human IgG1 Fc tag at the C-terminus. The protein migrates as 65-100 kDa under reducing (R) condition due to glycosylation.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Buffer
PBS, pH 7.4
Lagerung
-20 °C
Informationen zur Lagerung
-20°C
Target
IL-2 R beta & IL-2 R gamma
Andere Bezeichnung
IL-2 R beta&IL-2 R gamma
Hintergrund
Synonyms: IL-2 R beta & IL-2 R gamma,IL-2RB & IL-2RG, Description: Both Interleukin-2 receptor subunit beta and Interleukin-2 receptor subunit gamma are receptor for interleukin-2. Common subunit for the receptors for a variety of interleukins. Interacts with SHB upon interleukin stimulation. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.