Malic Enzyme Complex, Mitochondrial (Mod2) protein (Fc Tag)

Produktnummer ABIN7092746

Produktdetails

Target: Malic Enzyme Complex, Mitochondrial (Mod2)

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Fc Tag

Verwendungszweck: Recombinant Human MDR-1 with C-terminal human Fc tag

Spezifität: MDR-1 (Phe72-Arg113) (Lys213-Thr215) (Thr318-Gln330) (Gly960-Asp973) hFc (Glu99-Ala330)

Produktmerkmale: Extracellular Domain Protein

Aufreinigung: affinity purification

Reinheit: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute with deionized water

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: Malic Enzyme Complex, Mitochondrial (Mod2)

Andere Bezeichnung: MDR-1 (Mod2 Produkte)

Synonyme: Mdr Protein, Cd243 Protein, Mdr-1 Protein, Mod-2 Protein, Mod-2r Protein, Mod-2s Protein, Mod2-r Protein, Mod2-s Protein, ABC20 Protein, CD243 Protein, CLCS Protein, GP170 Protein, MDR1 Protein, P-GP Protein, PGY1 Protein, malic enzyme complex, mitochondrial Protein, ATP binding cassette subfamily B member 1 Protein, Mod2 Protein, ABCB1 Protein

Hintergrund: Synonymes: ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1
Description: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017]

Molekulargewicht: predicted molecular mass of 34.2 kDa after removal of the signal peptide.The apparent molecular mass of MDR-1-hFc is 25-55 kDa due to glycosylation.

UniProt: P08183