FURIN Protein (AA 27-574) (His tag)

Produktnummer ABIN7013596

Produktdetails

Target: FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))

Protein-Typ: Recombinant

Proteineigenschaft: AA 27-574

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses FURIN Protein ist gelabelt mit His tag.

Verwendungszweck: Human Furin / PCSK3 Protein, His Tag

Reinheit: >90 % as determined by SDS-PAGE.

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 20 mM Tris, 150 mM NaCl, pH 9.0

Lagerung: -80 °C

Antigendetails

Target: FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))

Andere Bezeichnung: Furin (FURIN Produkte)

Synonyme: FURIN Protein, furin Protein, si:dkey-281a24.5 Protein, FUR Protein, LOC100220259 Protein, PACE Protein, spc1 Protein, xfurin Protein, MGC82710 Protein, PCSK3 Protein, SPC1 Protein, 9130404I01Rik Protein, Fur Protein, Pcsk3 Protein, Pace Protein, furin, paired basic amino acid cleaving enzyme Protein, furin (paired basic amino acid cleaving enzyme) a Protein, furin (paired basic amino acid cleaving enzyme) b Protein, furin, paired basic amino acid cleaving enzyme L homeolog Protein, furin (paired basic amino acid cleaving enzyme) Protein, FURIN Protein, furina Protein, furinb Protein, furin Protein, furin.L Protein, Furin Protein

Hintergrund: Furin is also known as paired basic Amino acid Cleaving Enzyme (PACE), is an enzyme which belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. Furin is enriched in the Golgi apparatus, where it functions to cleave other proteins into their mature/active forms. The expression of furin in T-cells is required for maintenance of peripheral immune tolerance. Furin cleaves proteins just downstream of a basic amino acid target sequence (canonically, Arg-X-(Arg/Lys) -Arg'). PACE is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. In addition to processing cellular precursor proteins, furin is also utilized by a number of pathogens. For example, the envelope proteins of viruses such as HIV, influenza and dengue fever viruses must be cleaved by furin or furin-like proteases to become fully functional. PACE also play a role in tumor progression.

Molekulargewicht: 62.1 kDa

NCBI Accession: NM_002569

Pathways: Notch Signalweg, Neurotrophin Signalübertragung