Sialoadhesin/CD169 Protein (AA 20-1641) (His tag)

Produktnummer ABIN7013495

Produktdetails

Target: Sialoadhesin/CD169 (SIGLEC1) (Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin (SIGLEC1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 20-1641

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses Sialoadhesin/CD169 Protein ist gelabelt mit His tag.

Sequenz: AA 20-1641

Produktmerkmale: Cynomolgus Siglec-10 Protein, His Tag

Reinheit: >95 % as determined by SDS-PAGE.

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: MES,NaCl, pH 7.5

Lagerung: -20 °C

Antigendetails

Target: Sialoadhesin/CD169 (SIGLEC1) (Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin (SIGLEC1))

Andere Bezeichnung: Siglec-1 (SIGLEC1 Produkte)

Synonyme: Cd169 Protein, Siglec-1 Protein, Sn Protein, CD169 Protein, SIGLEC-1 Protein, SN Protein, dJ1009E24.1 Protein, SA Protein, SIGLEC1 Protein, p210 Protein, pSn Protein, sialic acid binding Ig like lectin 1 Protein, sialic acid binding Ig-like lectin 1, sialoadhesin Protein, SIGLEC1 Protein, Siglec1 Protein

Hintergrund: Alternate names for sialoadhesin include siglec-1 and CD169 (cluster of differentiation 169). Since sialoadhesin binds sialic acids with its N-terminal IgV-domain, it is also a member of the SIGLEC family. It is defined as an I-type lectin, since it contains 17 immunoglobulin (Ig) domains (one variable domain and 16 constant domains), and thus also belongs to the immunoglobulin superfamily (IgSF). Since sialoadhesin binds sialic acids with its N-terminal IgV-domain, it is also a member of the SIGLEC family. Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells.

Molekulargewicht: 175.1 kDa