CD3G Protein (AA 23-116) (Fc Tag)

Produktnummer ABIN7013164

Produktdetails

Target: CD3G (CD3g Molecule, gamma (CD3-TCR Complex) (CD3G))

Protein-Typ: Recombinant

Proteineigenschaft: AA 23-116

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses CD3G Protein ist gelabelt mit Fc Tag.

Produktmerkmale: Human CD3 gamma / CD3G Protein, Fc Tag (MALS verified)

Reinheit: >95 % as determined by SDS-PAGE.

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Applikationshinweise: MALS verified

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, pH 7.4

Lagerung: -20 °C

Antigendetails

Target: CD3G (CD3g Molecule, gamma (CD3-TCR Complex) (CD3G))

Andere Bezeichnung: CD3 gamma (CD3G Produkte)

Synonyme: Ctg-3 Protein, Ctg3 Protein, T3g Protein, CD3-GAMMA Protein, T3G Protein, CD3 antigen, gamma polypeptide Protein, CD3g molecule Protein, Cd3g Protein, CD3G Protein

Hintergrund: CD3 gamma chain is part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G.

Molekulargewicht: 37.1 kDa

Pathways: T-Zell Rezeptor Signalweg, CXCR4-mediated Signaling Events