Plexin B2 Protein (PLXNB2) (AA 20-1160) (His tag)

Produktnummer ABIN7013018

Produktdetails

Target: Plexin B2 (PLXNB2)

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 20-1160

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses Plexin B2 Protein ist gelabelt mit His tag.

Verwendungszweck: Human Plexin B2 Protein, His Tag

Reinheit: >90 % as determined by reduced SDS-PAGE.

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, pH 7.4

Lagerung: -20 °C

Antigendetails

Target: Plexin B2 (PLXNB2)

Andere Bezeichnung: Plexin B2 (PLXNB2 Produkte)

Synonyme: PLXNB2 Protein, MM1 Protein, Nbla00445 Protein, PLEXB2 Protein, dJ402G11.3 Protein, 1110007H23Rik Protein, Debt Protein, mKIAA0315 Protein, plexin B2 Protein, plexin B2 S homeolog Protein, PLXNB2 Protein, plxnb2.S Protein, plxnb2 Protein, Plxnb2 Protein

Hintergrund: Plexin B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor plays important roles in neural tube closure and cerebellar granule cell development. Mice lacking Plexin B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C-Plexin B2 signaling modulates ureteric branching. Plexin B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin B2 results in renal hypoplasia and occasional double ureters. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.

Molekulargewicht: 127.0 kDa

NCBI Accession: NP_036533

Pathways: Tube Formation