IL12A & IL27B (AA 20-189) (Active) protein (His tag)

Produktnummer ABIN6992356

Produktdetails

Target: IL12A & IL27B

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 20-189

Spezies: Human, Ratte

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: His tag

Verwendungszweck: Human IL-23 alpha & Rat IL-12 beta Heterodimer Protein, His Tag&Tag Free (MALS verified)

Reinheit: >90 % as determined by SDS-PAGE.

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, pH 7.4

Lagerung: -20 °C

Antigendetails

Target: IL12A & IL27B

Andere Bezeichnung: IL23A & IL12B

Hintergrund: Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Molekulargewicht: 20.6 kDa, 35.9 kDa