SIRP AlphaV2 (AA 31-369) (Active) protein (His tag,AVI tag,Biotin)

Produktnummer ABIN6973267

Produktdetails

Target: SIRP AlphaV2

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 31-369

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: His tag,AVI tag,Biotin

Sequenz: AA 31-369

Produktmerkmale: Human SIRP alphaV2 / CD172a Protein, His Tag

Reinheit: >95 % as determined by SDS-PAGE.

Endotoxin-Niveau: Less than 0.1 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, pH 7.4

Lagerung: -20 °C

Antigendetails

Target: SIRP AlphaV2

Hintergrund: Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

Molekulargewicht: 40.9 kDa