P2RX7 Protein (Fc Tag)

Produktnummer ABIN6964308

Produktdetails

Target: P2RX7 (Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses P2RX7 Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Recombinant human P2RX7 protein with N-terminal human Fc tag

Spezifität: HFc (Glu99-Ala330) P2RX7 (Ser47-Val334)

Produktmerkmale: Extracellular Domain Protein

Aufreinigung: affinity purification

Reinheit: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute with deionized water

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Konservierungsmittel: Without preservative

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: P2RX7 (Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7))

Andere Bezeichnung: P2RX7 (P2RX7 Produkte)

Synonyme: p2xr7 Protein, P2RX7 Protein, P2X7 Protein, AI467586 Protein, P2X(7) Protein, P2X7R Protein, p2x7 Protein, purinergic receptor P2X 7 Protein, purinergic receptor P2X, ligand-gated ion channel, 7 Protein, P2X purinoceptor 7 Protein, P2RX7 Protein, p2rx7 Protein, LOC100458463 Protein, P2rx7 Protein

Hintergrund: The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria.

Molekulargewicht: predicted molecular mass of 59.2 kDa after removal of the signal peptide. The apparent molecular mass of hFc-P2RX7 is 55-70 kDa due to glycosylation.

UniProt: Q99572

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Synaptic Vesicle Exocytosis