Macrophage Mannose Receptor 1 Protein (AA 19-1389) (His tag)

Produktnummer ABIN6952276

Produktdetails

Target: Macrophage Mannose Receptor 1 (MRC1) (Mannose Receptor, C Type 1 (MRC1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 19-1389

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses Macrophage Mannose Receptor 1 Protein ist gelabelt mit His tag.

Reinheit: >90 % as determined by SDS-PAGE.

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, pH 7.4

Lagerung: -20 °C

Antigendetails

Target: Macrophage Mannose Receptor 1 (MRC1) (Mannose Receptor, C Type 1 (MRC1))

Andere Bezeichnung: CD206 (MRC1 Produkte)

Synonyme: CD206 Protein, CLEC13D Protein, CLEC13DL Protein, MMR Protein, MRC1L1 Protein, bA541I19.1 Protein, AW259686 Protein, MR Protein, mrc1 Protein, MGC86525 Protein, MRC1 Protein, MRC1L-A Protein, mannose receptor C-type 1 Protein, mannose receptor, C type 1 Protein, mannose receptor C-type 1 L homeolog Protein, mediator of replication checkpoint 1 Protein, MRC1 Protein, Mrc1 Protein, mrc1.L Protein, mrc1 Protein

Hintergrund: Mrc1 is a conserved checkpoint mediator protein that transduces the replication stress signal to the downstream effector kinase. Mrc1 and its vertebrate homologue Claspin serve as a mediator for replication stress checkpoint signaling, receiving the signal from Mec1/Rad3/ATR sensor kinase and transmitting it to the effector Rad53/Cds1/Chk1 kinase. The loss of mrc1 checkpoint activity results in the aberrant activation of late/dormant origins in the presence of hydroxyurea. Tumor-associated macrophages (TAMs) expressing the multi-ligand endocytic receptor mannose receptor (CD206/MRC1) contribute to tumor immunosuppression, angiogenesis, metastasis, and relapse.

Molekulargewicht: 158.6 kDa

NCBI Accession: NP_002429