ITGAV/ITGB1 Protein (AA 31-992)

Produktnummer ABIN6952270

Produktdetails

Target: ITGAV/ITGB1 (Integrin alpha V + beta 1 (ITGAV/ITGB1))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 31-992

Spezies: Human

Quelle: HEK-293 Cells

Reinheit: >95 % as determined by SDS-PAGE.

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 50 mM Tris, 150 mM NaCl, pH 8.0

Lagerung: -20 °C

Antigendetails

Target: ITGAV/ITGB1 (Integrin alpha V + beta 1 (ITGAV/ITGB1))

Andere Bezeichnung: Integrin alpha V beta 1 (ITGAV/ITGB1 Produkte)

Hintergrund: Integrin alpha-5/beta-1 is a receptor for ibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-V/beta-1 is also a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition.

Molekulargewicht: 112.3 kDa (ITGAV) & 83.7 kDa (ITGB1)