DECR1 Protein (AA 35-335) (His tag)

Produktnummer ABIN7279383

Produktdetails

Target: DECR1 (2,4-Dienoyl CoA Reductase 1, Mitochondrial (DECR1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 35-335

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses DECR1 Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Produktmerkmale: DECR1, 35-335aa, Human, His tag, E.coli

Reinheit: > 90 % by SDS - PAGE

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol, 1mM DTT.

Lagerung: 4 °C

Antigendetails

Target: DECR1 (2,4-Dienoyl CoA Reductase 1, Mitochondrial (DECR1))

Andere Bezeichnung: DECR1 (DECR1 Produkte)

Synonyme: DECR Protein, NADPH Protein, SDR18C1 Protein, 1200012F07Rik Protein, Decr Protein, Nadph Protein, fe38b07 Protein, wu:fe38b07 Protein, zgc:92356 Protein, 2,4-dienoyl-CoA reductase 1 Protein, 2,4-dienoyl CoA reductase 1, mitochondrial Protein, 2,4-dienoyl-CoA reductase 1 L homeolog Protein, DECR1 Protein, Decr1 Protein, decr1 Protein, decr1.L Protein

Hintergrund: DECR1 is a mitochondrial protein that exists as a homotetramer and belongs to the family of short-chain dehydrogenases/reductases. It functions as an auxiliary enzyme of beta-oxidation andt participates in the metabolism of unsaturated fatty enoyl-CoA esters. Specifically, DECR1 uses NADP+ to catalyze the reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA, which can then be used as an intermediate in the Krebs cycle. Additionally, DECR1 is thought to function as a tumor suppressor, possibly downregulating the expression of Neu and slowing the rate of tumorigenesis. Recombinant human DECR1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: 2,4-dienoyl-CoA reductase, mitochondrial, DECR, NADPH, SDR18C1. NCBI no.: NP_001350

Molekulargewicht: 34.4 kDa (322aa), confirmed by MALDI-TOF

Pathways: Monocarboxylic Acid Catabolic Process